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Title: | Ensuring selectivity and sensitivity by timed- and ultra-selective reaction monitoring during gas chromatography tandem mass spectrometric determination of pesticides. |
Other Titles: | Not Available |
Authors: | Gayathree Nagarajan, Zareen S. Khan, Sagar C. Utture, Soma Dasgupta, Kaushik Banerjee. 2013. |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Research Centre for Grapes |
Published/ Complete Date: | 2013-11-29 |
Project Code: | Not Available |
Keywords: | Gas chromatography–triple quadrupole, mass spectrometry, Ultra selective reaction monitoring, Timed selective reaction monitoring, Quantitation enhanced data-dependent, scan, Multi-residue analysis |
Publisher: | Not Available |
Citation: | Gayathree Nagarajan, Zareen S. Khan, Sagar C. Utture, Soma Dasgupta, Kaushik Banerjee. 2013. Ensuring selectivity and sensitivity by timed- and ultra-selective reaction monitoring during gas chromatography tandem mass spectrometric determination of pesticides. Journal of Chromatography A. 1318:226-233. |
Series/Report no.: | Not Available; |
Abstract/Description: | In multiresidue analysis, as the complexity of matrix increases, matrix co-extractives might co-elute and interfere with the detection of target analytes, and thereby result in false positives and erroneous quantifications. This paper aims to evaluate the combination of enhanced mass resolution and concurrent selectivity and sensitivity in analyzing a complex mixture of 341 pesticides in grape, orange, tomato, okra and spinach by gas chromatography triple quadrupole mass spectrometry (GC–MS/MS). Timedselective reaction monitoring (t-SRM) was found advantageous over segment SRM in terms of ease of method optimization and sensitivity. The optimized t-SRM method was used to test the applicability of ultra-SRM (USRM) in filtering out co-eluting interfering matrix compounds. False detections of benfluralin, dimethoate, etc. could be avoided when mass resolution was increased from 0.7 to 0.4 and 0.2 Da (full width at half maximum). Similar observations were noted for chlorobenzilate, spiromesifen, tebuconazole, etc., in grape; omethoate, bendiocarb, monocrotophos, etc. in orange; omethoate, dimethoate, ethoxyquin, atrazine, etc., in tomato; and dichlobenil, omethoate, propoxur, monocrotophos, etc., in okra. The analysis at higher mass resolution could significantly minimize matrix effects (ME), e.g., 34% at 0.7 Da for spiroxamine in grape to 0.6% (0.4 Da) and −44% (0.7 Da) for dichlorvos in okra to 8.8% (0.1 Da). A feature called “quantitation enhanced data-dependent (QED) scan feature” was found effective in targeted screening to confirm the detection of atrazine, azoxystrobin, _-cyhalothrin, etc. at trace quantities in incurred samples and avoid false detection of chlorpyrifos. |
Description: | Not Available |
ISSN: | ISSN 0021-9673 |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Journal of Chromatography A |
NAAS Rating: | 10.05 |
Volume No.: | 1318 |
Page Number: | 226-233. |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | Not Available |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/26844 |
Appears in Collections: | HS-NRCG-Publication |
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