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http://krishi.icar.gov.in/jspui/handle/123456789/26880
Title: | Molecular characterization of MHC-DRB gene exon 2 in riverine buffalo (Bubalus bubalis) |
Other Titles: | Not Available |
Authors: | S Naskar, S M Deb, S K Niranjan, D Sakaram, D Sharma, S Kumar, A Sharma |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Research Centre on Pig |
Published/ Complete Date: | 2014-10-01 |
Project Code: | Not Available |
Keywords: | Buffalo, DRB, MHC, PCR-RFLP, phylogeny |
Publisher: | CSIR-NISCAIR |
Citation: | Not Available |
Series/Report no.: | Not Available; |
Abstract/Description: | In the present study, expressed DRB gene of buffalo major histocompatibility complex (Bubu) was characterized. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of Bubu-DRB second exon region using TaqI and HaeIII restriction enzymes revealed one and three restriction patterns, respectively. Comparative analysis of two different HaeIII variants revealed large number of amino acids substitutions at peptide binding site (PBS) of the molecule. The variants showed low divergence with cattle (BoLA) DRB3 alleles in general. Phylogenetically, Bubu-DRB clone b and e were found to be closer to Bubu-DRB*0501 and DRB*0401 alleles, respectively. High genetic variation at PBS region of Bubii-DRB exon 2 might contribute positively to antigen repertoire properties during infection. |
Description: | Not Available |
ISSN: | 0975-0967 |
Type(s) of content: | Article |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Indian Journal of Biotechnology |
NAAS Rating: | 6.41 |
Volume No.: | 13(4) |
Page Number: | 532-535 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | https://www.researchgate.net/publication/279334259_Molecular_characterization_of_MHC-DRB_gene_exon_2_in_riverine_buffalo_Bubalus_bubalis |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/26880 |
Appears in Collections: | AS-NRCP-Publication |
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