KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/8719
Title: | Meta-analysis GSTM1and GSTT1 polymorphisms and risk of Nasopharyngeal Cancer |
Other Titles: | Not Available |
Authors: | Murthy AK Kumar V Suresh KP |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics |
Published/ Complete Date: | 2013-01-01 |
Project Code: | Not Available |
Keywords: | Meta-analysis GSTM1 and GSTT1 Polymorphisms Risk of nasopharyngeal cancer |
Publisher: | Asia Pacific organization for cancer prevention |
Citation: | Not Available |
Series/Report no.: | Not Available; |
Abstract/Description: | Abstract BACKGROUND: Studies of associations between genetic polymorphism of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) with risk of nasopharyngeal cancer (NPC) have generated conflicting results. Thus, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on the risk of developing NPC. MATERIALS AND METHODS: A literature search in two electronic databases namely PubMed and EMBASE up to December 2012 was conducted and eligible papers were finally selected based on the inclusion and exclusion criteria. The pooled odds ratio (OR) and presence of heterogeneity and publication bias in those studies were evaluated. RESULTS: A total of 9 studies concerning nasopharyngeal cancer were evaluated. Analyses of all relevant studies showed increased NPC risk to be significantly associated with the null genotypes of GSTMI (OR=1.43, 95%CI 1.24-1.66) and GSTT1 (OR=1.28, 95%CI=1.09-1.51). In addition, evidence of publication bias was detected among the studies on GSTM1 polymorphism. CONCLUSIONS: This meta-analysis demonstrated the GSTM1 and GSTT1 null genotypes are associated with an increased risk of NPC. |
Description: | Not Available |
ISSN: | 1513-7368 |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Asian Pacific Journal of Cancer Prevention |
Volume No.: | 14(3) |
Page Number: | 1697-701 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | http://journal.waocp.org/article_27515_cd8efacb930088166636ba9a870b5f89.pdf |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/8719 |
Appears in Collections: | AS-NIVEDI-Publication |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
APJCP_Volume 14_Issue 3_Pages 1697-1701.pdf | 459.69 kB | Adobe PDF | View/Open |
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.