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http://krishi.icar.gov.in/jspui/handle/123456789/9278
Title: | Evaluation of humoral immune status in procine epidemic diarrhea virus (PEDV) infection sows under field conditions |
Other Titles: | Not Available |
Authors: | Ouyang K Shyu DL Dhakal S Hiremath J Binjawadagi B Lakshmanappa YS Guo R Ransburgh R Bondra KM Gauger P Zhang J Specht T Gilbertie A Minton W Fang Y Renukaradhya GJ |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | Ohio State University, USA ICAR::National Institute of Veterinary Epidemiology and Disease Informatics |
Published/ Complete Date: | 2015-12-01 |
Project Code: | Not Available |
Keywords: | Fecal Sample Vero Cell Mesenteric Lymph Node Oral Fluid Porcine Epidemic Diarrhea Virus |
Publisher: | BioMed Central |
Citation: | Not Available |
Series/Report no.: | Not Available; |
Abstract/Description: | Porcine epidemic diarrhea virus (PEDV) is an economically devastating enteric disease in the swine industry. The virus infects pigs of all ages, but it cause severe clinical disease in neonatal suckling pigs with up to 100% mortality. Currently, available vaccines are not completely effective and feedback methods utilizing PEDV infected material has variable success in preventing reinfection. Comprehensive information on the levels and duration of effector/memory IgA and IgG antibody secreting B cell response in the intestines and lymphoid organs of PEDV-infected sows, and their association with specific antibody levels in clinical samples such as plasma, oral fluid, and feces is important. Therefore, our goal in this study was to quantify PEDV specific IgA and IgG B cell responses in sows at approximately 1 and 6 months post-infection in commercial swine herds, including parity one and higher sows. Our data indicated that evaluation of both PEDV specific IgA and IgG antibody levels in the plasma and oral fluid (but not feces) samples is beneficial in disease diagnosis. PEDV specific B cell response in the intestine and spleen of infected sows decline by 6 months, and this associates with specific antibody levels in the plasma and oral fluid samples; but the virus neutralization titers in plasma remains high beyond 6 months post-infection. In conclusion, in sows infected with PEDV the presence of effector/memory B cell response and strong virus neutralization titers in plasma up to 6 months post-infection, suggests their potential to protect sows from reinfection and provide maternal immunity to neonates, but challenge studies are required to confirm such responses. |
Description: | Not Available |
ISSN: | 1746-6148 |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Veterinary Research |
NAAS Rating: | 9.36 |
Volume No.: | 46 |
Page Number: | 140 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | 10.1186/s13567-015-0285-x |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/9278 |
Appears in Collections: | AS-NIVEDI-Publication |
Files in This Item:
File | Description | Size | Format | |
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ba1d4a122241576c1e180ca7ce848cb657a3.pdf | 1.4 MB | Adobe PDF | View/Open |
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