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http://krishi.icar.gov.in/jspui/handle/123456789/10250| Title: | Nicotinic acetylcholine receptor alpha 1(nAChRα1) subunit peptides as potential antiviral agents against rabies virus |
| Other Titles: | Not Available |
| Authors: | Sajjanar B Dhusia K Saxena S Joshi V Bisht D Thakuria D Manjunathareddy G B Ramteke P W Kumar S |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR - National Institute of Veterinary Epidemiology and Disease Informatics Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Bareilly- 243122, Uttar Pradesh, India Department of Biological Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad-211007, Uttar Pradesh, India Department of Animal Biotechnology, College of Veterinary Sciences, Lala Lajapat Rai University of Veterinary & Animal Sciences, Hisar-125004, India Directorate of Cold water Fisheries, Indian Council of Agricultural Research, Anusandhan Bhawan, Bhimtal-263136, Uttarakhand, India |
| Published/ Complete Date: | 2017-11-01 |
| Project Code: | Not Available |
| Keywords: | Antivirals Glycoprotein peptide ligands Rabies virus |
| Publisher: | Elsevier |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Rabies virus (RABV) is neurotropic and infects all warm-blooded animals. The binding of the virus with host cell receptor components is critical for infection. The present study reports the interaction of nicotinic acetylcholine receptor alpha 1 (nAChRα1) peptides with the rabies virus glycoprotein (RABVG) to design potential anti-rabies agents. The nAChRα1peptide sequences from different species (bovine, human and electric fish/torpedo) were synthesized and their secondary structures were characterized using CD spectroscopy. The molecular docking analysis of nAChRα1 peptides with RABVG indicated the involvement of specific domains and their particular amino acid contributions. Bovine peptide (C-32) (docking score of 14146 kJ/mol) and torpedo peptide (T-32) (docking score of 13704 kJ/mol) were found to interact strongly with RABVG. T-32 peptides had the highest binding and inhibiting property against RABV compared to other peptide sequences. The results of both computational and experimental methods demonstrated that nAChRα1 peptides and their analogs may serve as potential antiviral agents against RABV infection. |
| Description: | Not Available |
| ISSN: | 0141-8130 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | International Journal of Biological Macromolecules |
| NAAS Rating: | 11.16 |
| Volume No.: | 104(A) |
| Page Number: | 180-188 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | 10.1016/j.ijbiomac.2017.05.179 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/10250 |
| Appears in Collections: | AS-NIVEDI-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 1-s2.0-S0141813017312643-main.pdf | 3.06 MB | Adobe PDF | View/Open |
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