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http://krishi.icar.gov.in/jspui/handle/123456789/19901| Title: | Molecular evidence and phylogenetic analysis of orf virus isolates from outbreaks in Tripura state of North-East India |
| Other Titles: | Not Available |
| Authors: | Venkatesan G De A Arya S Kumar A Muthuchelvan D Debnath BC Dutta TK Hemadri D Pandey AB |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | Division of Virology, ICAR-Indian Veterinary Research Institute, Mukteswar, Nainital District, Uttarakhand 263 138 India. Department of Veterinary Physiology and Biochemistry, College of Veterinary Sciences and A.H., R K Nagar, West Tripura, Tripura India. Department of Veterinary Microbiology, College of Veterinary Sciences and A.H., Selesih, Aizawl, Mizoram India. ICAR::National Institute of Veterinary Epidemiology and Disease Informatics |
| Published/ Complete Date: | 2018-03-22 |
| Project Code: | Not Available |
| Keywords: | B2L Contagious ecthyma Diagnostics Epidemiology Phylogeny Vaccines |
| Publisher: | Indian Virological Society |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | This study describes the first confirmed report of contagious ecthyma in Black Bengal goats from Tripura state, a North-Eastern state of India situated at the Indo-Bangladesh border. Outbreaks were characterized by the high rates of morbidity (58-67%), low mortality (8-10%) and case fatality (11-15%). The etiology of the outbreaks was confirmed as orf virus (ORFV) by standard virological/serological and molecular techniques including sequence analysis of B2L, a major envelop protein gene of genus Parapoxvirus. Sequence and phylogenetic analysis based on B2L gene of ORFV isolates from Tripura revealed that they were closely related to each other and also to other Indian isolates, in particular to ORFV-Shahjahanpur 82/04 isolate from North India. They revealed several specific nucleotide/amino acid substitutions, namely G299A (G100D), G660A, C705T, C795T (N267D) and G872A (R291H) which may be of notable epidemiological significance. This report necessitates the systematic investigation of orf outbreaks in susceptible populations including wild species particularly at transboundary regions by use of rapid diagnostics to control the infection by deploying an effective vaccine/therapeutics and better managemental practices. |
| Description: | Not Available |
| ISSN: | 2347-3517 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Virus Disease |
| NAAS Rating: | 5.95 |
| Volume No.: | 29(2) |
| Page Number: | 216-220 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1007/s13337-018-0442-8 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/19901 |
| Appears in Collections: | AS-NIVEDI-Publication |
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