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Title: | Evolutionary and Structural Analyses of Toll-Like Receptors 7 and 8 of Himalayan Kumaon Cattle and Goat |
Other Titles: | Not Available |
Authors: | Muniswamy Kangayan Shanmugam ChandraSekar Barathidasan Rajamani |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::Central Island Agricultural Research Institute |
Published/ Complete Date: | 2017-10-26 |
Project Code: | Not Available |
Keywords: | Innate immunity Toll-like receptor-7 Toll-like receptor-8 Leucine rich repeats Positive selection Ligand binding amino acid Phylogenetic analysis |
Publisher: | Springer |
Citation: | Kangayan, M., ChandraSekar, S., Rajamani, B. et al. Evolutionary and Structural Analyses of Toll-Like Receptors 7 and 8 of Himalayan Kumaon Cattle and Goat. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 89, 161–171 (2019). https://doi.org/10.1007/s40011-017-0928-y |
Series/Report no.: | Not Available; |
Abstract/Description: | Toll-like receptors (TLRs) are pattern recognition receptors that are critical for the functions of the host innate immunity. This study reports complete coding sequences of TLR-7 and TLR-8 of cattle and goat of Himalayan Kumaon (HK) region. Further, predicted 26 leucine rich repeats (LRRs), two terminal LRR modules and putative common and differential ligand binding amino acids in TLR-7 and -8 of ruminants. The differential ligand binding amino acids between TLR-7 and TLR-8 of HKcattle were Val396, Arg422, Val513, Asp538 and Val566 in TLR-8; Thr406, Lys432, Thr533, Leu558 and Ile586 in TLR-7. Codon selection analysis revealed co-localization of positively selected codons 377 and 408 of cattle, and 402 and 859 of goat with already reported SNPs in ruminants. The comparative analysis of deduced electrostatic surface potential of the extracellular domain of TLR-7 and -8 resulted in grouping of different species within ruminants. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Proceedings of the National Academy of Sciences India Section B: Biological Sci. |
Volume No.: | 89(1) |
Page Number: | 161-171 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | https://link.springer.com/article/10.1007/s40011-017-0928-y?shared-article-renderer |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/33705 |
Appears in Collections: | HS-CIARI-Publication |
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