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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/42703
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Indra Singh | en_US |
dc.contributor.author | Rajib Deb | en_US |
dc.contributor.author | Sanjeev Kumar | en_US |
dc.contributor.author | Rani Singh | en_US |
dc.contributor.author | Jerome Andonissamy | en_US |
dc.contributor.author | Shuchi Smita | en_US |
dc.contributor.author | Gyanendra Singh Sengar | en_US |
dc.contributor.author | Rajiv Kumar | en_US |
dc.contributor.author | Krishna Kumar Ojha | en_US |
dc.contributor.author | Nihar Ranjan Sahoo | en_US |
dc.contributor.author | S Murali | en_US |
dc.contributor.author | Rejani Chandran | en_US |
dc.contributor.author | Radhakrishnan V Nair | en_US |
dc.contributor.author | S B Lal | en_US |
dc.contributor.author | Dwijesh Chandra Mishra | en_US |
dc.contributor.author | Anil Rai | en_US |
dc.date.accessioned | 2020-11-26T05:38:23Z | - |
dc.date.available | 2020-11-26T05:38:23Z | - |
dc.date.issued | 2019-04-12 | - |
dc.identifier.citation | Not Available | en_US |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/42703 | - |
dc.description | Not Available | en_US |
dc.description.abstract | The pattern of interactions between foot and mouth disease (FMD) viral protein 1 (VP1) with susceptible and resistant host integrins were deciphered. The putative effect of site-directed mutation on alteration of interaction is illustrated using predicted and validated 3D structures of VP1, mutated VP1 and integrins of Bos taurus, Gallus and Canis. Strong interactions were observed between FMDV-VP1 protein motifs at conserved tripeptide, Arg-Gly-Asp 143RGD145 and at domain 676SIPLQ680 in alphaintegrin of B. taurus. Notably, in-silico site-directed mutation in FMDV-VP1 protein led to complete loss of interaction between FMD-VP1 protein and B. taurus integrin, which confirmed the active role of arginine-glycine-aspartic acid (RGD) domain. Interestingly, in-vitro analysis demonstrates the persistence of the putative tropism site ‘SIPLQ’ in different cattle breeds undertaken. Thus, the attempt to decipher the tropism of FMDV at host receptor level interaction might be useful for future FMD control strategies through development of mimetic marker vaccines and/or host receptor manipulations. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Not Available | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | FMD | en_US |
dc.subject | FMDV | en_US |
dc.subject | TGAV | en_US |
dc.subject | integrin | en_US |
dc.subject | interaction | en_US |
dc.subject | KR779877 | en_US |
dc.subject | tropism | en_US |
dc.title | Deciphering Foot-and-Mouth Disease (FMD) virus-host Tropism. Journal of Biomolecular Structure and Dynamics. Deciphering Foot-and-Mouth Disease (FMD) virus-host Tropism | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Journal of Biomolecular Structure & Dynamics | en_US |
dc.publication.volumeno | 37 | en_US |
dc.publication.pagenumber | 4779–4789 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | https://doi.org/10.1080/07391102.2019.1567386 | en_US |
dc.publication.authorAffiliation | ICAR::Indian Agricultural Statistics Research Institute | en_US |
dc.publication.authorAffiliation | ICAR::Central Institute for Research on Cattle | en_US |
dc.publication.authorAffiliation | ICAR::Central Institute for Research on Buffaloes | en_US |
dc.publication.authorAffiliation | ICAR::Central Institute for Research on Cattle | en_US |
dc.publication.authorAffiliation | ICAR::Central Sheep and Wool Research Institute | en_US |
dc.publication.authorAffiliation | Central University Of Bihar | en_US |
dc.publication.authorAffiliation | ICAR::Indian Veterinary Research Institute | en_US |
dc.publication.authorAffiliation | ICAR::National Bureau of Fish Genetic Resources | en_US |
dc.publication.authorAffiliation | ICAR::Central Institute of Fisheries Technology | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.naasrating | 6 | - |
Appears in Collections: | AEdu-IASRI-Publication |
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