KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/46566| Title: | Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes |
| Other Titles: | Not Available |
| Authors: | Hiremath J Renu S Tabynov K Renukaradhya GJ |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | Food Animal Health Research Program, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, USA Kazakh National Agrarian University, Almaty 050010, Kazakhstan and Research Institute of Cardiology and Internal Medicine, Almaty 050000, Kazakhstan ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, Karnataka, India |
| Published/ Complete Date: | 2020-02-21 |
| Project Code: | Not Available |
| Keywords: | Influenza A virus DAP12 M1 and M2 macrophages Pigs |
| Publisher: | Elsevier Publishers private limited |
| Citation: | Hiremath J, Renu S, Tabynov K and Renukaradhya GJ. (2020). Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes. Cellular Immunology. 352: 104078. 1-7. Jun; 352:104078. doi: 10.1016/j.cellimm.2020.104078. Epub 2020 Feb 21. PMID: 32164997. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | We delineated the expression of DAP12 (DNAX-Activating Protein) and its associated receptors, TREM-1, TREM-2 and MDL-1 in pig alveolar monocyte/macrophages (AMM) that have attained M1 or M2 phenotypes. Pig AMM stimulated in vitro with IFN-γ and IL-4 induced the expression of M1 (TNFα and iNOS) and M2 (ARG1 and no MMR) phenotypic markers, respectively. In influenza virus infected pigs at seven days post-infection, in addition to substantial modulations in the M1 and M2 markers expression, DAP12, TREM-1 and MDL-1 were downregulated in AMM. Thus, DAP12 signaling promoted the anti-inflammatory pathway in AMM of influenza virus infected pigs. |
| Description: | Not Available |
| ISSN: | 0008-8749 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Cellular Immunology |
| Journal Type: | International Journal |
| NAAS Rating: | 10.08 |
| Impact Factor: | 4.078 |
| Volume No.: | 352(2020) |
| Page Number: | 1-7 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://www.sciencedirect.com/science/article/pii/S0008874919304897 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/46566 |
| Appears in Collections: | AS-NIVEDI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.