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http://krishi.icar.gov.in/jspui/handle/123456789/51392
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jitendra K Biswal | en_US |
dc.contributor.author | Rajeev Ranjan | en_US |
dc.contributor.author | Bramhadev Pattnaik | en_US |
dc.date.accessioned | 2021-07-30T05:37:59Z | - |
dc.date.available | 2021-07-30T05:37:59Z | - |
dc.date.issued | 2016-09-01 | - |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/51392 | - |
dc.description.abstract | Objective: To determine whether the G-H loop of foot-and-mouth disease virus (FMDV) serotype O can function as a target structure to harbour and display serotype Asia1 antigenic epitope at the surface. Results: Using reverse genetics, FMDV serotype O IND R2/1975 displaying a FMDV serotype Asia1 B cell epitope at the capsid surface was constructed. The epitope-inserted recombinant chimeric virus was genetically stable up to ten serial passages in cell culture and exhibited growth properties similar to the parental serotype O virus. Furthermore, the surface-displayed Asia1 epitope able to react with serotype Asia1 specific antibodies in a competitive ELISA. Importantly, the recombinant chimeric virus showed neutralizing activity to both serotype O and Asia1 polyclonal antibodies. Conclusion: The capsid protein of FMDV serotype O can effectively display potent epitope of other serotypes, making this an attractive approach for the design of new generation bi-valent FMD vaccines. | en_US |
dc.language.iso | English | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Asia1 epitope; Chimeric foot-and-mouth disease virus; Epitope insertion; Foot-and-mouth disease virus; Reverse genetics | en_US |
dc.title | Chimeric foot-and-mouth disease virus serotype O displaying a serotype Asia1 antigenic epitope at the surface | en_US |
dc.type | Journal | en_US |
dc.publication.journalname | Biotechnology Letter | en_US |
dc.publication.volumeno | 38(9) | en_US |
dc.publication.pagenumber | 1509-17 | en_US |
dc.publication.sourceUrl | 10.1007/s10529-016-2121-4 | en_US |
dc.publication.authorAffiliation | ICAR::Project Directorate on Foot and Mouth Disease | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.journaltype | Research | en_US |
dc.publication.naasrating | 7.98 | en_US |
Appears in Collections: | AS-PDFMD-Publication |
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