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http://krishi.icar.gov.in/jspui/handle/123456789/5262
Title: | Efficient block designs for 2-colour microarray experiments |
Other Titles: | Not Available |
Authors: | Ananta Sarkar Rajender Parsad Abhishek Rathore V.K. Gupta |
Published/ Complete Date: | 2007-08 |
Project Code: | Not Available |
Keywords: | Microarray experiments mixed effects models A-efficiency D-efficiency |
Publisher: | Indian Society of Agricultural Statistics |
Citation: | Sarkar, Ananta, Parsad, Rajender, Rathore, Abhishek and Gupta, V.K. (2007). Efficient block designs for 2-colour microarray experiments. Journal of Indian Society of Agricultural Statistics, 61(2), 227-248. |
Series/Report no.: | Not Available; |
Abstract/Description: | This article deals with the problem of obtaining efficient designs for 2-colour microarray experiments. If arrays are considered as blocks and varieties as treatments and the number of varieties that can be accommodated on each arrary as block size, then a classical incomplete block design can be useful for microarray experiments. Since only two varieties can be accommodated on one array in 2-colour microarray experiment, effects due to arrays may be considered as random. To deal with the problem of obtaining an efficient design when array effects are random, lower bounds to A- and D-efficiencies of the design in a given class of designs have been obtained for block designs under a mixed effects model. For obtaining efficient block designs under fixed/mixed effects model for microarray experiments, the exchange and interchange algorithm of Rathore et. al. (2006) was modified by incorporating the procedure of translated into a computer program using Microsoft Visual C++. The algorithm is general in nature and can be used for generation of efficient block design for any 2<=k<=v, where v is the number of varieties (treatments) and k is the block size. The algorithm has been exploited for computer aided search of an efficient block design in v varieties and b-arrays for two colour micro-array experiments (k=2) in the parametric range 3 <= v <= 16, v<= b<= v (v-1)/2 and 17 <= v = b <= 25. Designs obtained through the algorithm under fixed effects model have been compared with the corresponding best designs available in the literature (designs with highest lower bound to A-efficiency) and 2-associate partially balanced incomplete block (PBIB(2)) designs. 30 designs are found to be more efficient than the best available block designs. The robustness aspects of efficient designs obtained under a fixed effects model and best available block designs were investigated under mixed effects model. Strength of the algorithm for obtaining block designs for 3-colour microarray experiments has also been demonstrated with the help of examples. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Journal of Indian Society of Agricultural Statistics |
NAAS Rating: | 5.51 5.51 |
Volume No.: | 61(2) |
Page Number: | 227-248 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | http://isas.org.in/jsp/onlinejournal.jsp |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/5262 |
Appears in Collections: | AEdu-IASRI-Publication |
Files in This Item:
File | Description | Size | Format | |
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ananta.pdf | 12.53 MB | Adobe PDF | View/Open |
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