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http://krishi.icar.gov.in/jspui/handle/123456789/5262
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ananta Sarkar | en_US |
dc.contributor.author | Rajender Parsad | en_US |
dc.contributor.author | Abhishek Rathore | en_US |
dc.contributor.author | V.K. Gupta | en_US |
dc.date.accessioned | 2017-09-05T08:08:08Z | - |
dc.date.available | 2017-09-05T08:08:08Z | - |
dc.date.issued | 2007-08 | - |
dc.identifier.citation | Sarkar, Ananta, Parsad, Rajender, Rathore, Abhishek and Gupta, V.K. (2007). Efficient block designs for 2-colour microarray experiments. Journal of Indian Society of Agricultural Statistics, 61(2), 227-248. | en_US |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/5262 | - |
dc.description | Not Available | en_US |
dc.description.abstract | This article deals with the problem of obtaining efficient designs for 2-colour microarray experiments. If arrays are considered as blocks and varieties as treatments and the number of varieties that can be accommodated on each arrary as block size, then a classical incomplete block design can be useful for microarray experiments. Since only two varieties can be accommodated on one array in 2-colour microarray experiment, effects due to arrays may be considered as random. To deal with the problem of obtaining an efficient design when array effects are random, lower bounds to A- and D-efficiencies of the design in a given class of designs have been obtained for block designs under a mixed effects model. For obtaining efficient block designs under fixed/mixed effects model for microarray experiments, the exchange and interchange algorithm of Rathore et. al. (2006) was modified by incorporating the procedure of translated into a computer program using Microsoft Visual C++. The algorithm is general in nature and can be used for generation of efficient block design for any 2<=k<=v, where v is the number of varieties (treatments) and k is the block size. The algorithm has been exploited for computer aided search of an efficient block design in v varieties and b-arrays for two colour micro-array experiments (k=2) in the parametric range 3 <= v <= 16, v<= b<= v (v-1)/2 and 17 <= v = b <= 25. Designs obtained through the algorithm under fixed effects model have been compared with the corresponding best designs available in the literature (designs with highest lower bound to A-efficiency) and 2-associate partially balanced incomplete block (PBIB(2)) designs. 30 designs are found to be more efficient than the best available block designs. The robustness aspects of efficient designs obtained under a fixed effects model and best available block designs were investigated under mixed effects model. Strength of the algorithm for obtaining block designs for 3-colour microarray experiments has also been demonstrated with the help of examples. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Indian Society of Agricultural Statistics | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Microarray experiments | en_US |
dc.subject | mixed effects models | en_US |
dc.subject | A-efficiency | en_US |
dc.subject | D-efficiency | en_US |
dc.title | Efficient block designs for 2-colour microarray experiments | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Journal of Indian Society of Agricultural Statistics | en_US |
dc.publication.volumeno | 61(2) | en_US |
dc.publication.pagenumber | 227-248 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | http://isas.org.in/jsp/onlinejournal.jsp | en_US |
dc.publication.naasrating | 5.51 | en_US |
dc.publication.naasrating | 5.51 | - |
Appears in Collections: | AEdu-IASRI-Publication |
Files in This Item:
File | Description | Size | Format | |
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ananta.pdf | 12.53 MB | Adobe PDF | View/Open |
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