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http://krishi.icar.gov.in/jspui/handle/123456789/6016
Title: | Revelation of Influencing Factors in Overall Codon Usage Bias of Equine Influenza Viruses |
Other Titles: | Not Available |
Authors: | Kumar N. Bera B.C. Greenbaum B.D. Bhatia S. Sood R. Selvaraj P. Anand T. Tripathi B.N. Virmani N. |
Published/ Complete Date: | 2016-04-01 |
Project Code: | Not Available |
Keywords: | H3N8 subtype Compositional RSCU Effective number of codon H7N7 |
Publisher: | Public Library of Science |
Citation: | Kumar N1, Bera BC2, Greenbaum BD3, Bhatia S1, Sood R1, Selvaraj P4, Anand T2, Tripathi BN4, Virmani N4. Revelation of Influencing Factors in Overall Codon Usage Bias of Equine Influenza Viruses.PLoS One. 2016 Apr 27;11(4):e0154376. |
Series/Report no.: | Not Available; |
Abstract/Description: | Equine influenza viruses (EIVs) of H3N8 subtype are culprits of severe acute respiratory infections in horses, and are still responsible for significant outbreaks worldwide. Adaptability of influenza viruses to a particular host is significantly influenced by their codon usage preference, due to an absolute dependence on the host cellular machinery for their replication. In the present study, we analyzed genome-wide codon usage patterns in 92 EIV strains, including both H3N8 and H7N7 subtypes by computing several codon usage indices and applying multivariate statistical methods. Relative synonymous codon usage (RSCU) analysis disclosed bias of preferred synonymous codons towards A/U-ended codons. The overall codon usage bias in EIVs was slightly lower, and mainly affected by the nucleotide compositional constraints as inferred from the RSCU and effective number of codon (ENc) analysis. Our data suggested that codon usage pattern in EIVs is governed by the interplay of mutation pressure, natural selection from its hosts and undefined factors. The H7N7 subtype was found less fit to its host (horse) in comparison to H3N8, by possessing higher codon bias, lower mutation pressure and much less adaptation to tRNA pool of equine cells. To the best of our knowledge, this is the first report describing the codon usage analysis of the complete genomes of EIVs. The outcome of our study is likely to enhance our understanding of factors involved in viral adaptation, evolution, and fitness towards their hosts. |
Description: | Not Available |
ISSN: | 1932-6203 |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | PLOS One |
NAAS Rating: | 8.74 |
Volume No.: | 11(4) |
Page Number: | e0154376 |
Source, DOI or any other URL: | 10.1371/journal.pone.0154376 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/6016 |
Appears in Collections: | AS-NIHSAD-Publication |
Files in This Item:
File | Description | Size | Format | |
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journal.pone.0154376.PDF | 2.47 MB | Adobe PDF | View/Open |
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