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Title: | First Molecular Evidence and Genetic Characterization of Ovine Herpesvirus 2 in Multiple Animal Species in India |
Other Titles: | Not Available |
Authors: | Kumar N Sood R Pateriya AK Venkatesakumar E Ramprabhu R Dixit R Bhatia S Singh VP |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Institute of High Security Animal Diseases Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Namakkal, India. Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Tirunelveli, India. |
Published/ Complete Date: | 2021-02-02 |
Project Code: | Not Available |
Keywords: | India; glycoprotein B; malignant catarrhal fever; multiple animals species; ovine herpesvirus 2. |
Publisher: | Frontiers Media SA |
Citation: | Kumar N, Sood R, Pateriya AK, Venkatesakumar E, Ramprabhu R, Dixit R, Bhatia S, Singh VP. First Molecular Evidence and Genetic Characterization of Ovine Herpesvirus 2 in Multiple Animal Species in India. Front Vet Sci. 2021 Feb 2;8:610178. doi: 10.3389/fvets.2021.610178. j |
Series/Report no.: | Not Available; |
Abstract/Description: | Ovine herpesvirus 2 (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever (SA-MCF), a highly fatal disease syndrome that predominantly affects susceptible hosts of the order Artiodactyla. In this study, an in-depth clinico-molecular investigation of SA-MCF disease in a morbid 50-days-old cattle calf (Bos taurus indicus) and asymptomatic infection in the in-contact reservoir hosts, sheep (Ovis aries), and goat (Capra hircus) housed on a farm located in the Southern India is reported. An OIE recommended SA-MCF type-specific PCR confirmed the etiological agent as OvHV-2. The genetic characterization and phylogenetic analyses based on the glycoprotein B (gB) gene indicate that three genetic variants of OvHV-2 had infected the animal cluster of this study. As the OvHV-2 infection eventually lead to the death of the cattle calf, and the fact that its gB sequence carried four unique amino acid substitutions (N169S, L594P, I645V, and V730A), an investigation of these substitutions impact on its stability and molecular flexibility was carried out. The mapping of these amino acid substitutions on the three-dimensional structure of gB coupled with supplementary investigations showed that these substitutions conveyed the molecular flexibility to the gB, at the cost of its stability. Future studies would be to investigate whether these gB substitutions have any impact on membrane fusion activity using a virus-free cell-to-cell membrane fusion assay. The study also highlights the importance of adopting stringent biosecurity measures where mixed animal farming is a common practice. |
Description: | Not Available |
ISSN: | 2297-1769 |
Type(s) of content: | Journal |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Frontiers in Veterinary Science |
Journal Type: | Peer Reviewed |
NAAS Rating: | 8.25 |
Impact Factor: | 2.42 |
Volume No.: | 8 |
Page Number: | 610178 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | 10.3389/fvets.2021.610178 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/66305 |
Appears in Collections: | AS-NIHSAD-Publication |
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