KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/66310
Title: | Identification and molecular characterization of H9N2 viruses carrying multiple mammalian adaptation markers in resident birds in central-western wetlands in India. |
Other Titles: | Not Available |
Authors: | Sood R Kumar N Gokhe SS Pateriya AK Bhat S Panickan S Mishra A Murugkar HV Dixit R Shrivastava D Singh P Tripathi M Singh VP |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Institute of High Security Animal Diseases Department of Veterinary Epidemiology and Preventive Medicine, Maharashtra Animal & Fishery Sciences University The Pirbright Institute, Woking GU24 0NF, UK. |
Published/ Complete Date: | 2021-07-20 |
Project Code: | Not Available |
Keywords: | H9N2 viruses; India; Resident birds; Wetlands; Zoonotic potential. |
Publisher: | Elsevier B.V. |
Citation: | Sood R, Kumar N, Gokhe SS, Pateriya AK, Bhat S, Bhatia S, Panickan S, Mishra A, Murugkar HV, Dixit R, Shrivastava D, Singh P, Tripathi M, Singh VP. Identification and molecular characterization of H9N2 viruses carrying multiple mammalian adaptation markers in resident birds in central-western wetlands in India. Infect Genet Evol. 2021 Oct;94:105005. |
Series/Report no.: | Not Available; |
Abstract/Description: | We report here a targeted risk-based study to investigate the presence of influenza A viruses at the migratory-wild-domestic bird interface across the major wetlands of central India's Maharashtra state during the winter migration season. The H9N2 viruses have been isolated and confirmed in 3.86% (33/854) of the fecal samples of resident birds. To investigate the genetic pools of H9N2 circulating in resident birds, we sequenced two isolates of H9N2 from distant wetlands. Sequence and phylogenetic analyses have shown that these viruses are triple reassortants, with HA, NA, NP, and M genes belonging to G1 sub-lineage (A/quail/Hong Kong/G1/1997), PB2, PB1, and NS genes originating from the prototype Eurasian lineage (A/mallard/France/090360/2009) and PA gene deriving from Y439/Korean-like (A/duck/Hong Kong/Y439/97) sub-lineage. It was confirmed not only that four of their gene segments had a high genetic association with the zoonotic H9N2 virus, A/Human/India/TCM2581/2019, but also that they had many molecular markers associated with mammalian adaptation and enhanced virulence in mammals including the unique multiple basic amino acids, KSKR↓GLF at the HA cleavage site, and analog N-and O-glycosylation patterns on HA with that of the zoonotic H9N2 virus. Furthermore, future experiments would be to characterize these isolates biologically to address the public health concern. Importantly, due to the identification of these viruses at a strategic geographical location in India (a major stop-over point in the Central Asian flyway), these novel viruses also pose a possible threat to be exported to other regions via migratory/resident birds. Consequently, systematic investigation and active monitoring are a prerequisite for identifying and preventing the spread of viruses of zoonotic potential by enforcing strict biosecurity measures. |
Description: | Not Available |
ISSN: | 1567-1348 |
Type(s) of content: | Journal |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Infection Genetics and Evolution |
Journal Type: | Peer Reviewed |
NAAS Rating: | 8.77 |
Impact Factor: | 2.77 |
Volume No.: | 94 |
Page Number: | 105005 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | 10.1016/j.meegid.2021.105005 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/66310 |
Appears in Collections: | AS-NIHSAD-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.