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http://krishi.icar.gov.in/jspui/handle/123456789/67187| Title: | Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats |
| Other Titles: | Not Available |
| Authors: | Sabeena Farvin, K. H. Anandan, R. Hari Senthil Kumar, S. Shiny, K. S. Suseela Mathew Sankar, T. V. Viswanathan Nair, P. G. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2006-01-04 |
| Project Code: | Not Available |
| Keywords: | isoprenaline lipid peroxidation lipids myocardial infarction squalene |
| Publisher: | Mary Ann Liebert,Inc |
| Citation: | Sabeena Farvin, K. H., Anandan, R., Hari Senthil Kumar, S., Shiny, K. S., Suseela Mathew, Sankar, T. V. and Viswanathan Nair, P. G. (2006) Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats. Journal of Medicinal Food. 9(4): 531-536. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | We studied the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart tissue. Prior administration of 2% squalene in feed for 45 days significantly reduced the isoprenaline-induced elevation in the levels of cholesterol, triglycerides, and free fatty acids in plasma and heart tissue of rats following myocardial infarction. It exerted an antilipidemic effect by reducing the level of low-density lipoprotein cholesterol with a parallel rise in the level of high-density lipoprotein cholesterol in plasma of experimental rats. A tendency to prevent the isoprenaline-induced depletion of phospholipids in the myocardium of experimental rats was also observed. In the present study, the pretreatment with squalene significantly counteracted the isoprenaline-induced lipid peroxidation and maintained the rats at near normal status. The results of the present study indicate that the overall cardioprotective effect of squalene is probably related to an inhibition of lipid accumulation by its hypolipidemic properties and/or its antioxidant properties. |
| Description: | Not Available |
| ISSN: | 1096-620X |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Journal of Medicinal Food |
| Journal Type: | International Journal |
| NAAS Rating: | 7.98 |
| Impact Factor: | 1.98 |
| Volume No.: | 9(4) |
| Page Number: | 531-536 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1089/jmf.2006.9.531 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/67187 |
| Appears in Collections: | FS-CIFT-Publication |
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