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http://krishi.icar.gov.in/jspui/handle/123456789/6893
Title: | Aryl-alkyl-lysines: Membrane active small molecules active against murine model of burn infection |
Other Titles: | Not Available |
Authors: | Ghosh C Manjunath GB Konai MM Divakara SSMU Krishnamoorthy P Shome BR Raju R Haldar J |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | Jawaharlal Nehru Centre For Advanced Scientific Research ICAR::National Institute of Veterinary Epidemiology and Disease Informatics |
Published/ Complete Date: | 2015-11-22 |
Project Code: | Not Available |
Keywords: | antibiotics; antimicrobial peptides; antimicrobial resistance; biofilm; burn infection; Gram-negative; persisters; |
Publisher: | American Chemical Society |
Citation: | Not Available |
Series/Report no.: | Not Available; |
Abstract/Description: | Infections caused by drug-resistant Gram-negative pathogens continue to be significant contributors to human morbidity. The recent advent of New Delhi metallo-β-lactamase-1 (blaNDM-1) producing pathogens, against which few drugs remain active, has aggravated the problem even further. This paper shows that aryl-alkyl-lysines, membrane-active small molecules, are effective in treating infections caused by Gram-negative pathogens. One of the compounds of the study was effective in killing planktonic cells as well as dispersing biofilms of Gram-negative pathogens. The compound was extremely effective in disrupting preformed biofilms and did not select resistant bacteria in multiple passages. The compound retained activity in different physiological conditions and did not induce any toxic effect in female Balb/c mice until concentrations of 17.5 mg/kg. In a murine model of Acinetobacter baumannii burn infection, the compound was able to bring the bacterial burden down significantly upon topical application for 7 days. |
Description: | Not Available |
ISSN: | 2373-8227 |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | ACS Infectious Diseases |
Volume No.: | 2(2) |
Page Number: | 111-122 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | DOI: 10.1021/acsinfecdis.5b00092 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/6893 |
Appears in Collections: | AS-NIVEDI-Publication |
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