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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/6893
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ghosh C | en_US |
dc.contributor.author | Manjunath GB | en_US |
dc.contributor.author | Konai MM | en_US |
dc.contributor.author | Divakara SSMU | en_US |
dc.contributor.author | Krishnamoorthy P | en_US |
dc.contributor.author | Shome BR | en_US |
dc.contributor.author | Raju R | en_US |
dc.contributor.author | Haldar J | en_US |
dc.date.accessioned | 2018-09-15T07:09:06Z | - |
dc.date.available | 2018-09-15T07:09:06Z | - |
dc.date.issued | 2015-11-22 | - |
dc.identifier.citation | Not Available | en_US |
dc.identifier.issn | 2373-8227 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/6893 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Infections caused by drug-resistant Gram-negative pathogens continue to be significant contributors to human morbidity. The recent advent of New Delhi metallo-β-lactamase-1 (blaNDM-1) producing pathogens, against which few drugs remain active, has aggravated the problem even further. This paper shows that aryl-alkyl-lysines, membrane-active small molecules, are effective in treating infections caused by Gram-negative pathogens. One of the compounds of the study was effective in killing planktonic cells as well as dispersing biofilms of Gram-negative pathogens. The compound was extremely effective in disrupting preformed biofilms and did not select resistant bacteria in multiple passages. The compound retained activity in different physiological conditions and did not induce any toxic effect in female Balb/c mice until concentrations of 17.5 mg/kg. In a murine model of Acinetobacter baumannii burn infection, the compound was able to bring the bacterial burden down significantly upon topical application for 7 days. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | American Chemical Society | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | antibiotics; antimicrobial peptides; antimicrobial resistance; biofilm; burn infection; Gram-negative; persisters; | en_US |
dc.title | Aryl-alkyl-lysines: Membrane active small molecules active against murine model of burn infection | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | ACS Infectious Diseases | en_US |
dc.publication.volumeno | 2(2) | en_US |
dc.publication.pagenumber | 111-122 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | DOI: 10.1021/acsinfecdis.5b00092 | en_US |
dc.publication.authorAffiliation | Jawaharlal Nehru Centre For Advanced Scientific Research | en_US |
dc.publication.authorAffiliation | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
Appears in Collections: | AS-NIVEDI-Publication |
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