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http://krishi.icar.gov.in/jspui/handle/123456789/71602| Title: | Insight of Codon usage bias and Evolutionary rate among the genes C, E, prM and NS5 of the Kyasanur Forest Disease virus |
| Other Titles: | Not Available |
| Authors: | Beelagi MS Indrabalan UB Patil SS Suresh KP Kollur SP Prasad A Srinivasa C Shivamallu C |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education & Research, Mysuru-570015, India ICAR::National Institute of Veterinary Epidemiology and Disease Informatics Department of Sciences, Amrita School of Arts and Sciences, Mysuru, Amrita Vishwa Vidyapeetham, Karnataka – 570 026, India Department of Microbiology, Faculty of Life Sciences, JSS Academy of Higher Education & Research, Mysuru-570015, India Department of Studies in Biotechnology, Davangere University, Shivagangotri, Davangere Karnataka-577 007, India |
| Published/ Complete Date: | 2021-05-31 |
| Project Code: | Not Available |
| Keywords: | KFD virus Codon usage bias Evolutionary characteristics Analysis Positive Selection tMRCA |
| Publisher: | JK Welfare & Pharmascope Foundation |
| Citation: | Beelagi MS, Indrabalan UB, Patil SS, Suresh KP, Kollur SP, Prasad A, Srinivasa C and Shivamallu C. (2021). Insight of Codon usage bias and Evolutionary rate among the genes C, E, prM and NS5 of the Kyasanur Forest Disease virus. International Journal of Research in Pharmaceutical Sciences, 12(3): 2028-2046. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Kyasanur Forest Disease was ϐirst evolved in the Kyasanur forest, Karnataka. The transmission of the virus has occurred from the monkey to the human by the tick vector. On the early day of viral spread, the disease was restricted to the surrounded region of Kyasanur forest, Shimoga district. But in the present days, the disease has been spreading to neighboring districts and states as well. So, this study involves estimation of codon bias among the gene C, gene E, gene prM, and gene NS5 of the KFD virus and rate of evolution with phylogenetic analysis. The codon usage analysis has revealed the moderate codon bias among all the selected genes and the role of mutation pressure in genesC and E and natural selection in genes- prM and NS5. Also, the tMRCA age was 1942, 1982, 1975, and 1931 of genes- C, E, prM, and NS5, respectively, of the KFD virus. The integrated analysis of codon usage bias and evolutionary rate analysis signiϐies that both mutational pressure and natural selection among the selected genes of the KFD virus |
| Description: | Not Available |
| ISSN: | 0975-7538 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | International Journal of Research in Pharmaceutical Sciences and Technology |
| Journal Type: | Peer reviewer journal |
| Volume No.: | 12 |
| Page Number: | 2028-2046 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.26452/ijrps.v12i3.4811 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/71602 |
| Appears in Collections: | AS-NIVEDI-Publication |
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