Evaluation of protective effects of gallic acid on cisplatin induced haematological alterations in rats

Abstract

The study was aimed to investigate the protective effect of phytochemical gallic acid on haematological alterations induced by cisplatin (CP) in Wistar albino rats. One hundred and eight Wistar albino rats were equally divided into six groups. Group I served as control group, Group II received single dose of intraperitoneal injection of CP at 7.5mg/kg bw, Group III received gallic acid at 75 mg/kg bw for 45 days, Group IV was treated with gallic acid daily for 15 days prior to CP injection and discontinued post cisplatin injection, Group V received CP injection and concurrently received gallic acid for 45 days post cisplatin injection and Group VI was treated with gallic acid for 15 days prior to CP injection and continued for 45 days post cisplatin injection. CP administration caused significant (p<0.05) decrease in TEC, haemoglobin, TLC and platelet count as compared to normal control group. Gallic acid supplementation to CP treated rats significantly improved the haematological parameters. It was concluded that, gallic acid supplementation could reduce the haematotoxicity and protect against cisplatin induced toxicity.