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http://krishi.icar.gov.in/jspui/handle/123456789/76653| Title: | Essential role of Rnd1 in innate immunity during viral and bacterial infections |
| Other Titles: | Not Available |
| Authors: | Kumar, A. Mishra, S. Kumar, A. Raut, A. A. Sato, S. Takaoka, A. Kumar, H. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India. Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA, USA. Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan. WPI Immunology, Frontier Research Centre, Osaka University, Osaka, Japan. ICAR::National Institute of High Security Animal Diseases |
| Published/ Complete Date: | 2022-06-02 |
| Project Code: | Not Available |
| Keywords: | Rnd1 |
| Publisher: | Nature Pub. Group |
| Citation: | Kumar, A., Mishra, S., Kumar, A., Raut, A. A., Sato, S., Takaoka, A., & Kumar, H. (2022). Essential role of Rnd1 in innate immunity during viral and bacterial infections. Cell death & disease, 13(6), 520. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Intracellular and cell surface pattern-recognition receptors (PRRs) are an essential part of innate immune recognition and host defense. Here, we have compared the innate immune responses between humans and bats to identify a novel membrane-associated protein, Rnd1, which defends against viral and bacterial infection in an interferon-independent manner. Rnd1 belongs to the Rho GTPase family, but unlike other small GTPase members, it is constitutively active. We show that Rnd1 is induced by pro-inflammatory cytokines during viral and bacterial infections and provides protection against these pathogens through two distinct mechanisms. Rnd1 counteracts intracellular calcium fluctuations by inhibiting RhoA activation, thereby inhibiting virus internalisation. On the other hand, Rnd1 also facilitates pro-inflammatory cytokines IL-6 and TNF-α through Plxnb1, which are highly effective against intracellular bacterial infections. These data provide a novel Rnd1-mediated innate defense against viral and bacterial infections. |
| Description: | Not Available |
| ISSN: | 2041-4889 |
| Type(s) of content: | Journal |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Cell death & disease |
| Journal Type: | Included NAAS journal |
| NAAS Rating: | 15.69 |
| Impact Factor: | 9.69 |
| Volume No.: | 13(6) |
| Page Number: | 520 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | 10.1038/s41419-022-04954-y |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/76653 |
| Appears in Collections: | AS-NIHSAD-Publication |
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