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http://krishi.icar.gov.in/jspui/handle/123456789/82296
Title: | Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications |
Other Titles: | Not Available |
Authors: | Bhavna Gupta, Vijayendra Kumar, Gaurav Kumar, Abdullah Khan, Najam Akhtar Shakil, Ashish Dhawan, Virinder S. Parmar, Jayant Kumar Arthur C. Watterson |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::Indian Agricultural Research Institute |
Published/ Complete Date: | 2011-11-01 |
Project Code: | Not Available |
Keywords: | Nanocarriers, amphiphilic copolymers, encapsulation, drug delivery, bio-active, micelles and Novozyme-435 |
Publisher: | Taylor and Francis |
Citation: | Bhavna Gupta, Vijayendra Kumar, Gaurav Kumar, Abdullah Khan, Najam A. Shakil, Ashish Dhawan, Virinder S. Parmar, Jayant Kumar & Arthur C. Watterson (2011): Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications, Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 48:12, 1009-1015 |
Series/Report no.: | Not Available; |
Abstract/Description: | Nano-particles with controllable particle size and shape are of great interest in biomedical applications (1). From the standpoint of drug carrier design with wide applicability to a variety of hydrophobic drugs, an effective strategy would be to prepare a simple copolymer having the property to form stable polymeric micelles which can entrap hydrophobic drugs in the core (2). In this study, we have attached saturated and unsaturated long chain acid chlorides to the copolymer of PEG and dimethyl-5-aminoisophthalate via an amide linkage in order to make the copolymers amphiphilic. Further, bioactive compounds like β-carotene, which has considerable double bond unsaturation and curcumin, which has considerable aromatic unsaturation, were encapsulated in these amphiphilic copolymers which successfully demonstrated their drug loading ability. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, |
Journal Type: | Research Journal |
NAAS Rating: | 7.16 |
Impact Factor: | 1.16 |
Volume No.: | 48(12), |
Page Number: | 1009-1015. |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | http://dx.doi.org/10.1080/10601325.2011.620427 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/82296 |
Appears in Collections: | CS-IARI-Publication |
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