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http://krishi.icar.gov.in/jspui/handle/123456789/82792
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rupesh Verma | en_US |
dc.contributor.author | Giridhari Das | en_US |
dc.contributor.author | Ajit Pratap Singh | en_US |
dc.contributor.author | Suman Kumar | en_US |
dc.contributor.author | Subhradal Nath | en_US |
dc.contributor.author | Pinaki Prasad Sengupta | en_US |
dc.date.accessioned | 2024-05-08T08:44:53Z | - |
dc.date.available | 2024-05-08T08:44:53Z | - |
dc.date.issued | 2023-07-13 | - |
dc.identifier.citation | Verma, R., Das, G., Singh, A.P., Kumar, S., Nath, S., Sengupta, P.P., Sankar, M., Tiwari, A., Gupta, V. and Srivastava, S. (2023). Molecular and genetic diversity in isolates of Trypanosoma evansi from naturally infected horse and dogs by using RoTat 1.2 VSG gene in Madhya Pradesh, India. Molecular Biology Reports 50 Doi: https://doi.org/10.1007/s11033-023-08651-7. | en_US |
dc.identifier.issn | 1573-4978 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/82792 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Background Trypanosoma evansi is a protozoan parasite that can infect a wide range of animals and is widespread around the world. In this study, we analyzed four fatal cases of T. evansi infection using clinical, parasitological, and molecular approaches. We also explored the genetic diversity, demographic history, and population-genetic structure of T. evansi using available Rode Trypanozoon antigenic type (RoTat) 1.2 gene sequences. Methods and results Clinical findings of infected animals revealed high fever, anemia, weakness, and anorexia. The animals were treated with diminazene aceturate, which was moderately effective, and hematobiochemical parameters showed changes in hemoglobin and glucose levels. The molecular and genetic diversity of T. evansi was analyzed using the RoTat 1.2 VSG gene. Phylogenetic and haplotype analysis revealed two distinct clusters of T. evansi circulating in India. The genetic diversity indices, neutrality tests, gene flow, and genetic differentiation outcomes confirmed the genetic diversity of the T. evansi population, with a lack of uniformity. The identification of two distinct clusters, exhibiting differential demographic histories and evolutionary forces, implies that the clusters may have undergone independent evolutionary trajectories or experienced different environmental pressures. Conclusion The present findings underlined the need of an early and precise diagnosis in order to treat and control T. evansi infections, and the RoTat 1.2 VSG gene is an important genetic marker for understanding the genetic diversity and evolutionary history of T. evansi. This knowledge can be used to create tailored strategies to control and manage the infection in an endemic region | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Trypanosoma evansi | en_US |
dc.subject | Dog | en_US |
dc.subject | Horse | en_US |
dc.subject | RoTat 1.2 VSG gene | en_US |
dc.subject | Phylogeny | en_US |
dc.subject | Genetic Diversity | en_US |
dc.title | Molecular and genetic diversity in isolates of Trypanosoma evansi from naturally infected horse and dogs by using RoTat 1.2 VSG gene in Madhya Pradesh, India | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Molecular Biology Reports | en_US |
dc.publication.volumeno | 50 | en_US |
dc.publication.pagenumber | 7347-7356 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | https://doi.org/10.1007/s11033-023-08651-7 | en_US |
dc.publication.authorAffiliation | Department of Veterinary Parasitology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur 482001, MP, India | en_US |
dc.publication.authorAffiliation | Animal Biotechnology Centre, JabalpurJawaharlal Nehru Krishi Vishwa Vidyalaya Campus, Jabalpur, 482004, (MP), Indi | en_US |
dc.publication.authorAffiliation | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics | en_US |
dc.publication.authorAffiliation | Division of Parasitology, ICAR-Indian Veterinary Research Institute, Bareilly 243122, (UP), India | en_US |
dc.publication.authorAffiliation | Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur 482001, MP, India | en_US |
dc.publication.authorAffiliation | Department of Veterinary Microbiology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur 482001, MP, India | en_US |
dc.publication.authorAffiliation | Department of Veterinary Biochemistry, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur 482001, MP, India | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.journaltype | Included in NAAS Journal List | en_US |
dc.publication.naasrating | 8.80 | en_US |
dc.publication.impactfactor | 2.80 | en_US |
Appears in Collections: | AS-NIVEDI-Publication |
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