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http://krishi.icar.gov.in/jspui/handle/123456789/14232| Title: | Gastroprotective effect of Sardine oil(Sardinella longiceps) against HCL/ethanol induced ulceration in Wistar rats |
| Other Titles: | Not Available |
| Authors: | Vishnu, K.V. Ajeeshkumar, K.K. Remyakumari, K.R. Ganesan, B. Chatterjee, N.S Lekshmi, R.G.K. Shyni, K. Suseela Mathew |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2017-02-20 |
| Project Code: | Not Available |
| Keywords: | Sardine oil anti-ulcer n-3 PUFA gastic mucosa |
| Publisher: | IIJFAS |
| Citation: | Vishnu, K.V., Ajeeshkumar, K.K., Remyakumari, K.R., Ganesan, B, Chatterjee, N.S., Lekshmi, R.G.K., Shyni, K. and Suseela Mathew (2017) - Gastroprotective effect of sardine oil (Sardinella longiceps) against HCl/ethanol induced ulceration in Wistar rats, Intl J. Fish. Aquatic Stud. 5(2):118-124. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Sardine oil is rich in n-3 polyunsaturated fatty acids (PUFAs) like EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). The oil showed a significant proportion of n-3 polyunsaturated fatty acids (PUFAs), the percentages of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) being 16 and 14% respectively. Gastroprotective activities of sardine oil (Sardinella longiceps) were examined in ulcer induced rats. Sardine oil has significant anti-secretory activity as evidenced by decreased gastric fluid volume, total acidity, and increase in the pH of the gastric fluid in ethanol/HCl induced rats. Our studies also revealed that pretreatment with sardine oil significantly reduced the number of ulcer, ulcer score and ulcer index in ethanol/HCl treated rats. The anti-ulcer activity of sardine oil is further supported by histopathological study, which showed protection of the mucosal layer from ulceration. Furthermore, this oil showed significant reversal of ethanol-diminished activity in antioxidant enzymes, such as SOD, CAT, and GSH. The overall findings conclude that oil of Sardinella longiceps has a significant proportion of n-3 polyunsaturated fatty acids and potent anti-ulcer effects. Hence, sardine oil may be a suitable natural source for the prevention and treatment of gastric lesions. |
| Description: | Not Available |
| ISSN: | 2347-5129(Online) 2394-0506 (Print) |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | International Journal of Fisheries and Aquatic Studies |
| Volume No.: | 5(2) |
| Page Number: | 118-124 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | http://dx.doi.org/10.22271/fish |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/14232 |
| Appears in Collections: | FS-CIFT-Publication |
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