KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/28818
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | NP Kurade | en_US |
dc.contributor.author | BN Tripathi | en_US |
dc.contributor.author | K Rajukumar | en_US |
dc.contributor.author | NS Parihar | en_US |
dc.date.accessioned | 2019-12-09T05:58:47Z | - |
dc.date.available | 2019-12-09T05:58:47Z | - |
dc.date.issued | 2004-07-01 | - |
dc.identifier.citation | N. P. Kurade, B. N. Tripathi, K. Rajukumar, N. S. Parihar 2004 Sequential Development of Histologic Lesions and Their Relationship with Bacterial Isolation, Fecal Shedding, and Immune Responses during Progressive Stages of Experimental Infection of Lambs with Mycobacterium avium subsp. paratuberculosis Veterinary Pathology Volume: 41 issue: 4, page(s): 378-387. | en_US |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/28818 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Understanding pathogenesis during progressive stages of infection by Mycobacterium avium subsp. paratuberculosis (MAP) and finding suitable methods for its diagnosis are key to the control of Johne's disease in animals. Paratuberculosis was experimentally produced in 20 crossbred lambs by oral administration of MAP to study the sequential development of lesions between 10 and 330 days postinfection and to assess commonly used diagnostic methods such as bacterial culture, lymphocyte stimulation test (LST), and enzyme-linked immunosorbent assay (ELISA) during progressive stages of infection. Histologic lesions were classified into four grades from grade 1 (least severe) to grade 4 (most severe) on the basis of location of granulomatous lesions in different regions and layers of intestines, their association with intestinal lymphoid tissues, pattern and distribution of lesions, types of cellular infiltration, and presence of acid-fast bacilli. It is evident that infection first establishes in lymphoid tissues of the small intestine, possibly at multiple sites, producing segmental lesions and from there spreads to lamina propria and local lymph nodes. Wide variability in the histologic lesions in relation to postinfection periods and initial tropism of MAP to the intestinal lymphoid tissues (Peyer's patches) suggests a differential susceptibility of young animals, possibly because of compositional phenotypic variation of Peyer's patches influencing subsequent course of infection. Histopathology was found to be a better indicator of paratuberculous infection than bacteriology in sheep. The LST (reflecting the cellular immune response) and ELISA (reflecting the humoral immune response) had overall sensitivities of 65% (11 of 17) and 42% (8 of 19), respectively, in sheep with different types of pathology but when employed together could detect about 88% of infected animals. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | SAGE Publications | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Bacteriologic culture, enzyme-linked immunosorbent assay, histopathology, immune responses, lymphocyte stimulation test, paratuberculosis, pathogenesis, sheep | en_US |
dc.title | Sequential development of histologic lesions and their relationship with bacterial isolation, fecal shedding, and immune responses during progressive stages of experimental Infection of Lambs with Mycobacterium avium subsp. paratuberculosis | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Veterinary Pathology | en_US |
dc.publication.volumeno | 41 | en_US |
dc.publication.pagenumber | 378-387 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | Not Available | en_US |
dc.publication.authorAffiliation | ICAR National Institute of Abiotic Stress Management, | en_US |
dc.publication.authorAffiliation | ICAR::National Institute of High Security Animal Diseases | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.naasrating | 8.01 | en_US |
Appears in Collections: | NRM-NIASM-Publication |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
vp.41-4-378.pdf | 477.11 kB | Adobe PDF | View/Open |
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.