Effect of Dietary Inclusion of Mycodetox B2 on Liveability, Immunity and Organ Pathology During Aflatoxicosis in Turkey Poults

Abstract

To evaluate the efficacy of Mycodetox B2 in ameliorating aflatoxicosis, day-old Turkey poults (n=200) were divided into five treatment groups, viz. T1: control; T2: T1+100ppb aflatoxin B1 (AFB1); T3: T1+150ppb AFB1; T4: T2+Mycodetox B2; T5: T3+Mycodetox B2. Each diet was fed to four replicates of 10 birds each for 42 days. The study revealed that overall liveability percent in T3 was lower (P<0.05) than T1. The CMI and HA titre values of T2 and T3 was lower (P<0.05) than T1. The CMI and HA titre values in T4 and T5 was higher (P<0.05) than T2 and T3 and similar to T1. The haemoglobin (Hb) value in T2 and T3 was lower (P<0.05) than T1. The Hb value in T4 and T5 was higher (P<0.05) than T2 and T3; and similar to T1. The H/L ratio of T1 was lower (P<0.05) than T2 and T3. The H/L ratio of T4 and T5 was lower (P<0.05) than T2 and T3 and similar to T1. Grossly, in T2 and T3 petechiae were seen in the kidneys and lungs; ecchymotic haemorrhages were also observed in liver and leg muscles; petechial haemorrhages were also recorded in thymus and bursa. The organs of T4 and T5 were normal as in T1. Histopathologically, liver of T2 and T3, revealed congestion of central vein, mild degenerative changes in the hepatocytes and areas of necrosis associated with mild mononuclear (MNCs) cells infiltration especially in the portal areas. Hepatocytes also showed moderate fatty change, mild hyperplastic changes in the small bile ducts and lymphoid aggregation in the form of nodules. Haemorrhages in the liver parenchyma were quite marked. In T4 and T5, the architectural and cellular organization in the liver was normal as in T1. It was concluded that dietary AFB1 at 100 or 150ppb levels resulted in reduced liveability, immunity; decreased haemoglobin concentration, increased H/L ratio; and morphological and histopathological alterations in the internal organs. Moreover, the dietary incorporation of Mycodetox B2 ameliorated the adverse effects of aflatoxicosis in Turkey poults.