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http://krishi.icar.gov.in/jspui/handle/123456789/32158| Title: | Blood biochemistry, thyroid hormones, and oxidant/antioxidant status of guinea pigs challenged with sodium arsenite or arsenic trioxide |
| Other Titles: | Not Available |
| Authors: | Ranjan Kumar Mohanta Anil Kumar Garg R.S. Dass Suvendu Kumar Behera |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Indian Veterinary Research Institute ICAR::National Rice Research Institute |
| Published/ Complete Date: | 2014-06-21 |
| Project Code: | Not Available |
| Keywords: | Arsenic Blood biochemistry Oxidative Stress Thyroid Profile Guinea Pigs |
| Publisher: | Springer Nature |
| Citation: | Mohanta, R.K., Garg, A.K., Dass, R.S. et al. Blood Biochemistry, Thyroid Hormones, and Oxidant/Antioxidant Status of Guinea Pigs Challenged with Sodium Arsenite or Arsenic Trioxide. Biol Trace Elem Res 160, 238–244 (2014). https://doi.org/10.1007/s12011-014-0041-5 |
| Series/Report no.: | Not Available; |
| Abstract/Description: | The present experiment aimed to compare the two most commonly used compounds of arsenic (sodium arsenite and arsenic trioxide) for their effect on blood metabolites, thyroid hormones, and oxidant/antioxidant status in guinea pigs. Twenty-one adult guinea pigs were randomly divided into three equal groups. Animals in group T1 (control) were fed a basal diet, whereas 50 ppm arsenic was added in the basal diet either as sodium arsenite (T2) or arsenic trioxide (T3) and fed for 11 weeks. Serum aspartate aminotransferase and alanine aminotransferase activities were significantly increased along with a decrease in blood hemoglobin level in both the arsenic-administered groups. The level of erythrocytic antioxidants (catalase, superoxide dismutase, reduced glutathione, glutathione-S-transferase, and glutathione reductase) was decreased and lipid peroxidation was elevated upon arsenic exposure. Serum thyroid hormone levels were reduced and arsenic levels in tissues increased in both the arsenic-exposed groups, irrespective of the arsenic compound. Thus, sodium arsenite and arsenic trioxide exerted similar adverse effects on blood metabolic profile, antioxidant status, and thyroid hormones in guinea pigs. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Biological Trace Element Research |
| NAAS Rating: | 8.64 |
| Volume No.: | 160(2) |
| Page Number: | 238-244 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1007/s12011-014-0041-5 https://link.springer.com/article/10.1007/s12011-014-0041-5 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/32158 |
| Appears in Collections: | CS-NRRI-Publication |
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