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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/35388
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Saha C | en_US |
dc.contributor.author | Kothapalli P | en_US |
dc.contributor.author | Patil V | en_US |
dc.contributor.author | Reddy GBM | en_US |
dc.contributor.author | Kaveri SV | en_US |
dc.contributor.author | Bayry J | en_US |
dc.date.accessioned | 2020-05-04T09:31:47Z | - |
dc.date.available | 2020-05-04T09:31:47Z | - |
dc.date.issued | 2019-05-07 | - |
dc.identifier.citation | Not Available | en_US |
dc.identifier.issn | 21645515 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/35388 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Intravenous immunoglobulin (IVIG) is one of the widely used immunotherapeutic molecules in the therapy of autoimmune and inflammatory diseases. Previous reports demonstrate that one of the anti-inflammatory actions of IVIG implicates suppression of macrophage activation and release of their inflammatory mediators. However, macrophages are highly plastic and depending on the microenvironmental signals, macrophages can be polarized into pro-inflammatory classic (M1) or anti-inflammatory alternative (M2) type. This plasticity of macrophages raised additional questions on the role of IVIG towards macrophage polarization. In the present report, we show that IVIG affects the polarization of both classically and alternatively activated macrophages and this process is F(ab')2-independent. Our data thus indicate the lack of reciprocal regulation of inflammatory and non-inflammatory macrophages by IVIG. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Taylor and Francis Publications | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | IVIG | en_US |
dc.subject | IgG | en_US |
dc.subject | inflammation | en_US |
dc.subject | innate cells | en_US |
dc.subject | macrophage | en_US |
dc.subject | monocyte | en_US |
dc.title | Intravenous immunoglobulin suppresses the polarization of both classically and alternatively activated macrophages | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Human Vaccines and Immunotherapeutics | en_US |
dc.publication.volumeno | 16(2) | en_US |
dc.publication.pagenumber | 233-239 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | https://doi.org/10.1080/21645515.2019.1602434 | en_US |
dc.publication.authorAffiliation | Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Equipe-Immunopathologie et Immunointervention Thérapeutique, Sorbonne Université, Université Paris Descartes, Paris, France | en_US |
dc.publication.authorAffiliation | UMR CNRS 6022, Université de Technologie de Compiègne, Compiègne, France | en_US |
dc.publication.authorAffiliation | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
Appears in Collections: | AS-NIVEDI-Publication |
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