KRISHI
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http://krishi.icar.gov.in/jspui/handle/123456789/35394Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Akshata SA | en_US |
| dc.contributor.author | Rao S | en_US |
| dc.contributor.author | Satyanarayana ML | en_US |
| dc.contributor.author | Narayanaswamy HD | en_US |
| dc.contributor.author | Byregowda SM | en_US |
| dc.contributor.author | Reddy GBM | en_US |
| dc.date.accessioned | 2020-05-04T09:34:11Z | - |
| dc.date.available | 2020-05-04T09:34:11Z | - |
| dc.date.issued | 2019-08-02 | - |
| dc.identifier.citation | Not Available | en_US |
| dc.identifier.issn | 2278-3687 | - |
| dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/35394 | - |
| dc.description | Not Available | en_US |
| dc.description.abstract | The present study was conducted to assess methotrexate (MTX) induced toxicity in Wistar male albino rats. The study had two groups with 12 rats in each. MTX was used at the dose of 5mg/kg b.w. to induce toxicity. In MTX control group the levels of endogenous antioxidant enzymes such as SOD, CAT and GPx were significantly reduced compared to those of normal control. The MDA levels caused by lipid peroxidation as a result of oxidant injury to liver was significantly higher in MTX positive controlthan compared to that of normal control. In conclusion MTX induces hepatotoxicity in rats through oxidative stress evidenced by decreased levels of endogenous antioxidant enzymes such as SOD, CAT and GPx and increased levels of MDA indicating increased extent of oxidative injury caused by MTX on hepatocytes. | en_US |
| dc.description.sponsorship | Not Available | en_US |
| dc.language.iso | English | en_US |
| dc.publisher | International Journal of Science Environment and Technology | en_US |
| dc.relation.ispartofseries | Not Available; | - |
| dc.subject | Methotrexate | en_US |
| dc.subject | oxidative stress | en_US |
| dc.subject | endogenous anti oxidant enzymes | en_US |
| dc.title | Effect of Methotrexate Induced Oxidative Stress in The Liver of Wistar Albino Rats | en_US |
| dc.title.alternative | Not Available | en_US |
| dc.type | Research Paper | en_US |
| dc.publication.projectcode | Not Available | en_US |
| dc.publication.journalname | International Journal of Science, Environment and Technology | en_US |
| dc.publication.volumeno | 8(4) | en_US |
| dc.publication.pagenumber | 840-844 | en_US |
| dc.publication.divisionUnit | Not Available | en_US |
| dc.publication.sourceUrl | http://www.ijset.net/journal/2397.pdf | en_US |
| dc.publication.authorAffiliation | Department of Veterinary Pathology, Veterinary College, KVAFSU, Hebbal, Bengaluru - 560 024 | en_US |
| dc.publication.authorAffiliation | KVAFSU, Bidar - 585 401 | en_US |
| dc.publication.authorAffiliation | IAH & VB, Bellary Rd, Vinayakanagar, Sanjaynagar, Bengaluru - 560 024 | en_US |
| dc.publication.authorAffiliation | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics | en_US |
| dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
| Appears in Collections: | AS-NIVEDI-Publication | |
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