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http://krishi.icar.gov.in/jspui/handle/123456789/45293
Title: | Antigenic variability of foot-and-mouth disease virus serotype O during serial cytolytic passage |
Other Titles: | Not Available |
Authors: | Subramaniam S, Das B, Biswal JK, Ranjan R, Pattnaik B |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::Project Directorate on Foot and Mouth Disease |
Published/ Complete Date: | 2017-07-17 |
Project Code: | Not Available |
Keywords: | Antigenic variability; Cytolytic passage; FMDV; Serotype O; Site IV |
Publisher: | Springer |
Citation: | Subramaniam S, Das B, Biswal JK, Ranjan R, Pattnaik B (2017) Antigenic variability of foot-and-mouth disease virus serotype O during serial cytolytic passage. Virus Genes.53(6):931-934 |
Series/Report no.: | Not Available; |
Abstract/Description: | The emergence and disappearance of antigenic variants of foot-and-mouth disease virus (FMDV) during a field outbreak occurs periodically due to the volatile nature of its genome. In the present analysis, change in antigenic behavior of serotype O FMDV during the serial cytolytic passage in the absence of immune pressure was observed. Initially, the isolate showed a poor antigenic match (relationship value <0.3) with the serotype O vaccine strain and upon serial passage increase in relationship value was observed. Comparison of capsid sequence revealed substitution at four positions (VP3:K58 → E and P158 → S, VP1:E83 → K and R172 → Q) acquired during the serial passage. Examination of passage level and amino acid substitution revealed the critical role of position VP3-58 that was identified earlier as crucial for antigenic site IV, in the observed antigenic variability. The role of position VP3-58 was further confirmed using reverse genetics approach |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Virus Genes |
NAAS Rating: | 7.99 |
Volume No.: | 53(6) |
Page Number: | 931-934 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | 10.1007/s11262-017-1494-3 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/45293 |
Appears in Collections: | AS-PDFMD-Publication |
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