KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/46644
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Abhinav Choubey | en_US |
dc.contributor.author | Budheswar Dehury | en_US |
dc.contributor.author | Sunil Kumar | en_US |
dc.contributor.author | Bikash Medhi | en_US |
dc.contributor.author | Prosenjit Mondal | en_US |
dc.date.accessioned | 2021-04-23T07:43:22Z | - |
dc.date.available | 2021-04-23T07:43:22Z | - |
dc.date.issued | 2020-09-15 | - |
dc.identifier.citation | : Abhinav Choubey , Budheswar Dehury , Sunil Kumar , Bikash Medhi & Prosenjit Mondal (2020): Naltrexone a potential therapeutic candidate for COVID-19, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2020.1820379 | en_US |
dc.identifier.other | PMID: 32930058 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/46644 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease (COVID-19) that has resulted in a global pandemic. At the time of writing, approximately 16.06 million cases have been reported worldwide. Like other coronaviruses, SARS-CoV-2 relies on the surface Spike glycoprotein to access the host cells, mainly through the interaction of its Receptor Binding Domain (RBD) with the host receptor Angiotensin-Converting Enzyme2 (ACE2). SARS-CoV-2 infection induces a profound downstream pro-inflammatory cytokine storm. This release of the pro-inflammatory cytokines is underpinning lung tissue damage, respiratory failure, and eventually multiple organ failure in COVID-19 patients. The phosphorylation status of ERK1/2 is positively correlated with virus load and ERK1/2 inhibition suppressed viral replication and viral infectivity. Therefore, molecular entities able to interfere with binding of the SARS-CoV-2 Spike protein to ACE2, or damping hyperinflammatory cytokines storm, blocking ERK1/2 phosphorylation have a great potential to inhibit viral entry along with viral infectivity. Herein, we report that the FDA-approved non-peptide opioid antagonist drug, naltrexone suppresses high fat/LPS induced pro-inflammatory cytokine release both from macrophage cells and Adipose Tissue Macrophage. Moreover, Low Dose Naltrexone (LDN) also showed its activity as an ERK1/2 inhibitor. Notably, virtual docking and simulation data also suggest LDN may disrupt the interaction of ACE2 with RBD. LDN may be considered as a target as the treatment and (or) adjuvant therapy for coronavirus infection. Clinical toxicity measurements may not be required for LDN since naltrexone was previously tested and is an approved drug by the FDA. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | COVID-19 | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | drug repurposing | en_US |
dc.subject | molecular docking | en_US |
dc.subject | naltrexone | en_US |
dc.subject | structural bioinformatics | en_US |
dc.title | Naltrexone a potential therapeutic candidate for COVID-19 | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Journal of Biomolecular Structure & Dynamics | en_US |
dc.publication.volumeno | Not Available | en_US |
dc.publication.pagenumber | 1-8 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | doi: 10.1080/07391102.2020.1820379 | en_US |
dc.publication.authorAffiliation | ICAR::Indian Agricultural Statistics Research Institute | en_US |
dc.publication.authorAffiliation | Indian Institute of Technology, Mandi | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.naasrating | 9.2 | en_US |
dc.publication.naasrating | 6 | - |
dc.publication.impactfactor | 3.2 | en_US |
Appears in Collections: | AEdu-IASRI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.