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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/46800
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahlawat S, Arora R, Sharma R, Sharma U, Kaur M, Kumar A, Singh KV, Singh MK and Vijh RK | en_US |
dc.date.accessioned | 2021-04-28T05:08:20Z | - |
dc.date.available | 2021-04-28T05:08:20Z | - |
dc.date.issued | 2020-04-08 | - |
dc.identifier.citation | Ahlawat, S., Arora, R., Sharma, R. et al. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production. Sci Rep 10, 6050 (2020). https://doi.org/10.1038/s41598-020-63023-6 | en_US |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/46800 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Pashmina, the world’s finest natural fiber is derived from secondary hair follicles of Changthangi goats which are domesticated in Ladakh region of Jammu and Kashmir by nomadic pastoralists. Complex epithelial-mesenchymal interactions involving numerous signal molecules and signaling pathways govern hair follicle morphogenesis and mitosis across different species. The present study involved transcriptome profiling of skin from fiber type Changthangi goats and meat type Barbari goats to unravel gene networks and metabolic pathways that might contribute to Pashmina development. In Changthangi goats, 525 genes were expressed at significantly higher levels and 54 at significantly lower levels with fold change >2 (padj < 0.05). Functional annotation and enrichment analysis identified significantly enriched pathways to be formation of the cornified envelope, keratinization and developmental biology. Expression of genes for keratins (KRTs) and keratin-associated proteins (KRTAPs) was observed to be much higher in Changthangi goats. A host of transcriptional regulator genes for hair follicle keratin synthesis such as GPRC5D, PADI3, HOXC13, FOXN1, LEF1 and ELF5 showed higher transcript abundance in Pashmina producing goats. Positive regulation of Wnt signaling pathway and negative regulation of Oncostatin M signaling pathway may be speculated to be important contributors to hair follicle development and hair shaft differentiation in Changthangi goats. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Not Available | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Changthangi goats, Indian goats, transcriptomic profile | en_US |
dc.title | Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production. | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Article | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Scientific Reports | en_US |
dc.publication.volumeno | 10, 6050 | en_US |
dc.publication.pagenumber | Not Available | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | https://doi.org/10.1038/s41598-020-63023-6 | en_US |
dc.publication.authorAffiliation | ICAR- National Bureau of Animal Genetic Resources | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.naasrating | 10 | en_US |
Appears in Collections: | AS-NBAGR-Publication |
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