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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/4728
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Arunima Kumar Verma | en_US |
dc.contributor.author | Shipra Gupta | en_US |
dc.contributor.author | Sharad Verma | en_US |
dc.contributor.author | Abha Mishra | en_US |
dc.contributor.author | N. S. Nagpure | en_US |
dc.contributor.author | Shivesh Pratap Singh | en_US |
dc.contributor.author | Ajey Kumar Pathak | en_US |
dc.contributor.author | Uttam Kumar Sarkar | en_US |
dc.contributor.author | Shri Prakash Singh | en_US |
dc.contributor.author | Mahender Singh | en_US |
dc.contributor.author | Prahlad Kishore Seth | en_US |
dc.date.accessioned | 2017-07-18T06:35:26Z | - |
dc.date.available | 2017-07-18T06:35:26Z | - |
dc.date.issued | 2012-11-23 | - |
dc.identifier.citation | Verma, A.K., Gupta, S., Verma, S., Mishra, A., Nagpure, N.S., Singh, S.P., Pathak, A.K., Sarkar, U.K., Singh, S.P., Singh, M. and Seth, P.K., 2013. Interaction between shrimp and white spot syndrome virus through PmRab7-VP28 complex: an insight using simulation and docking studies. Journal of molecular modeling, 19(3), pp.1285-1294. | en_US |
dc.identifier.other | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/4728 | - |
dc.description | National Agricultural Bioinformatics Grid Project under National Agricultural Innovation Project. | en_US |
dc.description.abstract | White spot disease is a devastating disease of shrimp Penaeus monodon in which the shrimp receptor protein PmRab7 interacts with viral envelop protein VP28 to form PmRab7-VP28 complex, which causes initiation of the disease. The molecular mechanism implicated in the disease, the dynamic behavior of proteins as well as interaction between both the biological counterparts that crafts a micro-environment feasible for entry of virus into the shrimp is still unknown. In the present study, we applied molecular modeling (MM), molecular dynamics (MD) and docking to compute surface mapping of infective amino acid residues between interacting proteins. Our result showed that α-helix of PmRab7 (encompassing Ser74, Ile143, Thr184, Arg53, Asn144, Thr184, Arg53, Arg79) interacts with β-sheets of VP28 (containing Ser74, Ile143, Thr184, Arg53, Asn144, Thr184, Arg53, Arg79) and Arg69-Ser74, Val75-Ile143, Leu73-Ile143, Arg79-Asn144, Ala198-Ala182 bonds contributed in the formation of PmRab7-VP28 complex. Further studies on the amino acid residues and bonds may open new possibilities for preventing PmRab7-VP28 complex formation, thus reducing chances of WSD. The quantitative predictions provide a scope for experimental testing in future as well as endow with a straightforward evidence to comprehend cellular mechanisms underlying the disease. | en_US |
dc.description.sponsorship | Indian Council of Agricultural research, New Delhi. | en_US |
dc.language.iso | English | en_US |
dc.publisher | SPRINGER LINK | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Docking | en_US |
dc.subject | Molecular dynamics | en_US |
dc.subject | Molecular modeling | en_US |
dc.subject | Shrimp | en_US |
dc.subject | Simulation | en_US |
dc.subject | White spot disease | en_US |
dc.title | Interaction between shrimp and white spot syndrome virus through PmRab7-VP28 complex: an insight using simulation and docking studies | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Journal of Molecular Modeling | en_US |
dc.publication.volumeno | 19(3) | en_US |
dc.publication.pagenumber | 1285-1294 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | 10.1007/s00894-012-1672-0 | en_US |
dc.publication.naasrating | 7.35 | en_US |
Appears in Collections: | FS-NBFGR-Publication |
Files in This Item:
File | Description | Size | Format | |
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Arunima.pdf | 794.91 kB | Adobe PDF | View/Open |
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