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http://krishi.icar.gov.in/jspui/handle/123456789/48086| Title: | Epididymosomes: A potential male fertility influencer |
| Other Titles: | Not Available |
| Authors: | Nilendu Paul, Thirumala Rao Talluri, Pradeep Nag and Arumugam Kumaresan |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::National Dairy Research Institute |
| Published/ Complete Date: | 2021-06-04 |
| Project Code: | Not Available |
| Keywords: | epididymis, epididymosomes, male fertility, sperm maturation, sperm proteins |
| Publisher: | Andrologia |
| Citation: | Paul, N., Talluri, T. R., Nag, P., & Kumaresan, A. (2021). Epididymosomes: A potential male fertility influencer. Andrologia, 00, e14155. https://doi. org/10.1111/and.14155 |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Not Available |
| Description: | During transit and storage in epididymis, spermatozoa undergo final maturation, acquire motility, functional competence and the ability to fertilise an oocyte. Epididymal secretions contain a complex biochemical milieu of diverse inorganic ions, proteins, metabolites and other molecules. Since it is believed that spermatozoa are translationally silent, proteins appearing in them are thought to be synthesised elsewhere, including epididymis, and then incorporated to the cells. One of the important mechanisms suggested to be involved in transfer of epididymal secretions to spermatozoa is through exosomes called epididymosomes. Epididymosomes released from the epididymal epithelium contain proteins, noncoding RNAs and distinct set of lipids that are transferred to spermatozoa while they pass through the different epididymal regions. Owing to the importance of these molecules for sperm maturation and fertilising ability, research on epididymosomes has gained increasing attention during the last decade. This review is focused on epididymosomes, with emphasis on recent advances in the understanding of mechanisms of epididymosomal cargo transfer to spermatozoa and potential roles of epididymosomes in sperm function and beyond. Possibilities of utilising the molecular signatures of epididymosomes as a tool for male fertility assessment are also discussed |
| ISSN: | 1439-0272 |
| Type(s) of content: | Review Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Andrologia |
| NAAS Rating: | 7.95 |
| Impact Factor: | 2.775 |
| Volume No.: | Not Available |
| Page Number: | 1-14 |
| Name of the Division/Regional Station: | Equine Production campus, ICAR-NRC on Equines, Southern Regional Staion, ICAR-NDRI |
| Source, DOI or any other URL: | DOI: 10.1111/and.14155 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/48086 |
| Appears in Collections: | AS-NRCE-Publication |
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