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http://krishi.icar.gov.in/jspui/handle/123456789/49215
Title: | Transcriptome profiling of different developmental stages of corpus luteum during the estrous cycle in pigs |
Other Titles: | Not Available |
Authors: | Jaya Bharati, NH Mohan, Satish Kumar, Jayashree Gogoi, Sai Kumar, Bosco Jose, Meeti Punetha, Sanjib Borah, Amit Kumar, Mihir Sarkar |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Research Centre on Pig |
Published/ Complete Date: | 2021-01-01 |
Project Code: | IXX15063 |
Keywords: | Corpus luteum, Transcriptome, Angiogenesis, Steroidogenesis, Proliferation, Luteolysis |
Publisher: | Elsevier |
Citation: | Bharati, Jaya, N. H. Mohan, Satish Kumar, Jayashree Gogoi, Sai Kumar, Bosco Jose, Meeti Punetha, Sanjib Borah, Amit Kumar, and Mihir Sarkar. "Transcriptome profiling of different developmental stages of corpus luteum during the estrous cycle in pigs." Genomics 113, no. 1 (2021): 366-379. |
Series/Report no.: | Not Available; |
Abstract/Description: | To better understand the molecular basis of corpus luteum (CL) development and function RNA-Seq was utilized to identify differentially expressed genes (DEGs) in porcine CL during different physiological stages of the estrous cycle viz. early (EL), mid (ML), late (LL) and regressed (R) luteal. Stage wise comparisons obtained 717 (EL vs. ML), 568 (EL vs. LL), 527 (EL vs. R), 786 (ML vs. LL), 474 (ML vs. R) and 534 (LL vs. R) DEGs with log2(FC) ≥1 and p < 0.05. The process of angiogenesis, steroidogenesis, signal transduction, translation, cell proliferation and tissue remodelling were significantly (p < 0.05) enriched in EL, ML and LL stages, where as apoptosis was most active in regressed stage. Pathway analysis revealed that most annotated genes were associated with lipid metabolism, translation, immune and endocrine system pathways depicting intra-luteal control of diverse CL function. The network analysis identified genes AR, FOS, CDKN1A, which were likely the novel hub genes regulating CL physiology. |
Description: | Not Available |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Genomics |
Journal Type: | Peer Reviewed |
NAAS Rating: | 12.21 |
Impact Factor: | 6.21 |
Volume No.: | 113(1) |
Page Number: | 366-379 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | https://doi.org/10.1016/j.ygeno.2020.12.008 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/49215 |
Appears in Collections: | AS-NRCP-Publication |
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