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http://krishi.icar.gov.in/jspui/handle/123456789/51834
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jajati Keshari Mohapatra | en_US |
dc.contributor.author | Biswajit Das | en_US |
dc.contributor.author | Manoranjan Rout | en_US |
dc.contributor.author | B P Sreenivasa | en_US |
dc.contributor.author | Saravanan Subramaniam | en_US |
dc.contributor.author | Aniket Sanyal | en_US |
dc.contributor.author | Bramhadev Pattnaik | en_US |
dc.date.accessioned | 2021-08-01T12:05:07Z | - |
dc.date.available | 2021-08-01T12:05:07Z | - |
dc.date.issued | 2018-05-31 | - |
dc.identifier.citation | Mohapatra JK, Das B, Rout M, Sreenivasa BP, Subramaniam S, Sanyal A, Pattnaik B. Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India. Vaccine. 2018 May 31;36(23):3191-3194. doi: 10.1016/j.vaccine.2018.04.090. Epub 2018 May 4. PMID: 29735325. | en_US |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/51834 | - |
dc.description | Not Available | en_US |
dc.description.abstract | National foot-and-mouth disease (FMD) control programme’ is being implemented in India and therefore predicting vaccine match is a key surveillance task. Recently, a considerable proportion of field viruses (75.6%) showed antigenic drift from the existing serotype A vaccine strain A IND 40/2000 necessitating search for an alternate strain. Here, antigenic relationship (‘r1’ value) of 87 field viruses with each of the 8 candidate strains was estimated by virus neutralization test. A IND 27/2011 strain emerged to be the one with the widest spectrum of antigenic coverage showing ‘r1’ value of more than 0.3 with 81.6% of field strains. It achieved a reasonably high titre of log10 7.5 TCID50/ml in BHK-21 suspension cell which was accompanied by positive charge gaining substitutions (E82–K and E131–K in VP2) thought to have adaptive significance. However, potency trial remains to be conducted before A IND 27/2011 finds a place in the vaccine formulation. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Alternate vaccine strain selection, FMD virus serotype A, India, VNT | en_US |
dc.title | Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Vaccine | en_US |
dc.publication.volumeno | 36 | en_US |
dc.publication.pagenumber | 3191-3194 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | https://www.sciencedirect.com/science/article/pii/S0264410X18306145?via%3Dihub#kg005 | en_US |
dc.publication.authorAffiliation | ICAR::Project Directorate on Foot and Mouth Disease | en_US |
dc.publication.authorAffiliation | ICAR::Indian Veterinary Research Institute | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.naasrating | 9.14 | en_US |
Appears in Collections: | AS-PDFMD-Publication |
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