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http://krishi.icar.gov.in/jspui/handle/123456789/6011
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tosh C. | en_US |
dc.contributor.author | Nagarajan S. | en_US |
dc.contributor.author | Kumar M. | en_US |
dc.contributor.author | Murugkar H.V. | en_US |
dc.contributor.author | Venkatesh G. | en_US |
dc.contributor.author | Shukla S. | en_US |
dc.contributor.author | Mishra A. | en_US |
dc.contributor.author | Mishra P. | en_US |
dc.contributor.author | Agarwal S. | en_US |
dc.contributor.author | Singh B. | en_US |
dc.contributor.author | Dubey P. | en_US |
dc.contributor.author | Tripathi S. | en_US |
dc.contributor.author | Kulkarni D.D. | en_US |
dc.date.accessioned | 2018-03-22T07:53:41Z | - |
dc.date.available | 2018-03-22T07:53:41Z | - |
dc.date.issued | 2016-09-01 | - |
dc.identifier.citation | Tosh C, Nagarajan S, Kumar M, Murugkar HV, Venkatesh G, Shukla S, Mishra A, Mishra P, Agarwal S, Singh B, Dubey P, Tripathi S, Kulkarni DD. Multiple introductions of a reassortant H5N1 avian influenza virus of clade 2.3.2.1c with PB2 gene of H9N2 subtype into Indian poultry.Infect Genet Evol. 2016 Sep;43:173-8. | en_US |
dc.identifier.issn | 1567-1348 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/6011 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Highly pathogenic avian influenza (HPAI) H5N1 viruses are a threat to poultry in Asia, Europe, Africa and North America. Here, we report isolation and characterization of H5N1 viruses isolated from ducks and turkeys in Kerala, Chandigarh and Uttar Pradesh, India between November 2014 and March 2015. Genetic and phylogenetic analyses of haemagglutinin gene identified that the virus belonged to a new clade 2.3.2.1c which has not been detected earlier in Indian poultry. The virus possessed molecular signature for high pathogenicity to chickens, which was corroborated by intravenous pathogenicity index of 2.96. The virus was a reassortant which derives its PB2 gene from H9N2 virus isolated in China during 2007-2013. However, the neuraminidase and internal genes are of H5N1 subtype. Phylogenetic and network analysis revealed that after detection in China in 2013/2014, the virus moved to Europe, West Africa and other Asian countries including India. The analyses further indicated multiple introductions of H5N1 virus in Indian poultry and internal spread in Kerala. One of the outbreaks in ducks in Kerala is linked to the H5N1 virus isolated from wild birds in Dubai suggesting movement of virus probably through migration of wild birds. However, the outbreaks in ducks in Chandigarh and Uttar Pradesh were from an unknown source in Asia which also contributed gene pools to the outbreaks in Europe and West Africa. The widespread incidence of the novel H5N1 HPAI is similar to the spread of clade 2.2 ("Qinghai-like") virus in 2005, and should be monitored to avoid threat to animal and public health. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Duck | en_US |
dc.subject | H5N1 subtype | en_US |
dc.subject | Highly pathogenic avian influenza | en_US |
dc.subject | India | en_US |
dc.subject | Reassortment | en_US |
dc.subject | Turkey | en_US |
dc.title | Multiple introductions of a reassortant H5N1 avian influenza virus of clade 2.3.2.1c with PB2 gene of H9N2 subtype into Indian poultry | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Infection Genetics and Evolution | en_US |
dc.publication.volumeno | 43 | en_US |
dc.publication.pagenumber | 173-8 | en_US |
dc.publication.divisionUnit | Diagnostic II Lab | en_US |
dc.publication.sourceUrl | 10.1016/j.meegid.2016.05.012 | en_US |
dc.publication.naasrating | 8.77 | en_US |
Appears in Collections: | AS-NIHSAD-Publication |
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