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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/70593
Title: | Precise plant genome editing using base editors and prime editors |
Other Titles: | Not Available |
Authors: | Kutubuddin A Molla, Simon Sretenovic, Kailash C Bansal, Yiping Qi |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Rice Research Institute |
Published/ Complete Date: | 2021-09-13 |
Project Code: | Not Available |
Keywords: | CRISPR–Cas, genome editing, Prime editing, Plants, Precision editing |
Publisher: | Springer |
Citation: | Molla, K.A., Sretenovic, S., Bansal, K.C. et al. Precise plant genome editing using base editors and prime editors. Nat. Plants 7, 1166–1187 (2021). https://doi.org/10.1038/s41477-021-00991-1 |
Series/Report no.: | Not Available; |
Abstract/Description: | The development of CRISPR–Cas systems has sparked a genome editing revolution in plant genetics and breeding. These sequence-specific RNA-guided nucleases can induce DNA double-stranded breaks, resulting in mutations by imprecise non-homologous end joining (NHEJ) repair or precise DNA sequence replacement by homology-directed repair (HDR). However, HDR is highly inefficient in many plant species, which has greatly limited precise genome editing in plants. To fill the vital gap in precision editing, base editing and prime editing technologies have recently been developed and demonstrated in numerous plant species. These technologies, which are mainly based on Cas9 nickases, can introduce precise changes into the target genome at a single-base resolution. This Review provides a timely overview of the current status of base editors and prime editors in plants, covering both technological developments and biological applications. |
Description: | Not Available |
Type(s) of content: | Review Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Nature Plants |
Journal Type: | Review paper |
Volume No.: | Not Available |
Page Number: | 1166–1187 |
Name of the Division/Regional Station: | Crop improvement division |
Source, DOI or any other URL: | https://www.nature.com/articles/s41477-021-00991-1 |
URI: | https://www.nature.com/articles/s41477-021-00991-1 http://krishi.icar.gov.in/jspui/handle/123456789/70593 |
Appears in Collections: | CS-NRRI-Publication |
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