KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/75548
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ankita Gurao, Rashi Vasisth, Ravinder Singh, M.S. Dige, V. Vohra, M. Mukesh, Sanjay Kumar and R.S. Kataria | en_US |
dc.date.accessioned | 2023-01-17T05:18:10Z | - |
dc.date.available | 2023-01-17T05:18:10Z | - |
dc.date.issued | 2022-10-14 | - |
dc.identifier.citation | Not Available | en_US |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/75548 | - |
dc.description | Not Available | en_US |
dc.description.abstract | The DNA methylation events mark a major epigenetic change in the genome, reflecting non-genetic disease developments and varied phenotypes. The water buffalo is a dairy production animal with wide agro-climatic distribution in India. Breed-wise the coat color of water buffalo varies from ash-gray to jet black. A typical pigmentation pattern is found in one of the breeds of North India, Nili Ravi, with variedly distributed white patches. The DNA methylation pattern could potentially reveal the epigenetic factors responsible for the pigmentation patterns. To address this question, the DNA isolated from the skin tissues of Nili Ravi with varied white pigmentation and black Murrah buffaloes was subjected to reduced representation bisulfite sequencing. DNA methylation analysis revealed, 68.44%, 63.39%, and 47.94% of the promoter regions were hypermethylated in Nili Ravi over-white versus Murrah, Nili Ravi under-white versus Murrah, and Nili Ravi under-white versus Nili Ravi over-white, respectively. Major genes identified to be differentially methylated among over-white and under-white skin tissues in Nili Ravi included TBX2, SNAI2, HERC2, and CITED1. Overall the results have indicated differential methylation patterns to be potentially involved in hyper or hypopigmentation in Nili Ravi and Murrah buffaloes. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Not Available | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | bisulfite sequencing, buffalo, differential methylation, Murrah, Nili Ravi, skin pigmentation | en_US |
dc.title | Identification of differential methylome signatures of white pigmented skin patches in Nili Ravi buffalo of India | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Article | en_US |
dc.publication.projectcode | 2.12 | en_US |
dc.publication.journalname | Environmental and Molecular Mutagenesis | en_US |
dc.publication.volumeno | Not Available | en_US |
dc.publication.pagenumber | Not Available | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | Not Available | en_US |
dc.publication.authorAffiliation | ICAR::National Bureau of Animal Genetic Resources | en_US |
dc.publication.authorAffiliation | ICAR::National Dairy Research Institute | en_US |
dc.publication.authorAffiliation | ICAR::Central Institute for Research on Buffaloes | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.naasrating | 9.22 | en_US |
dc.publication.impactfactor | 3.57 | en_US |
Appears in Collections: | AS-NBAGR-Publication |
Files in This Item:
File | Description | Size | Format | |
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EMM-Reprint.pdf | 2 MB | Adobe PDF | View/Open |
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