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http://krishi.icar.gov.in/jspui/handle/123456789/76077| Title: | Evaluation of protective effects of gallic acid on cisplatin induced haematological alterations in rats |
| Other Titles: | Not Available |
| Authors: | Roopadevi YS Rao S Nadoor P Byregowda SM Narayanaswamy HD Krishnamoorthy P Girish MH |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | Veterinary College, Hebbal, Bangalore Veterinary College, Vinob Nagar, Shimoga Institute of Animal Health and Veterinary Biologicals, Hebbal, Bangalore ICAR::National Institute of Veterinary Epidemiology and Disease Informatics |
| Published/ Complete Date: | 2023-02-06 |
| Project Code: | Not Available |
| Keywords: | Gallic acid cisplatin haematotoxicity nephroprotection |
| Publisher: | The Pharma Innovation Journal |
| Citation: | 1. Roopadevi YS, Rao S, Nadoor P, Byregowda SM, Narayanaswamy HD, Krishnamoorthy P, Girish MH. 2023. Evaluation of protective effects of gallic acid on cisplatin induced hematological alteration in rats. The Pharma Innovation Journal, 12(2): 626-632. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | The study was aimed to investigate the protective effect of phytochemical gallic acid on haematological alterations induced by cisplatin (CP) in Wistar albino rats. One hundred and eight Wistar albino rats were equally divided into six groups. Group I served as control group, Group II received single dose of intraperitoneal injection of CP at 7.5mg/kg bw, Group III received gallic acid at 75 mg/kg bw for 45 days, Group IV was treated with gallic acid daily for 15 days prior to CP injection and discontinued post cisplatin injection, Group V received CP injection and concurrently received gallic acid for 45 days post cisplatin injection and Group VI was treated with gallic acid for 15 days prior to CP injection and continued for 45 days post cisplatin injection. CP administration caused significant (p<0.05) decrease in TEC, haemoglobin, TLC and platelet count as compared to normal control group. Gallic acid supplementation to CP treated rats significantly improved the haematological parameters. It was concluded that, gallic acid supplementation could reduce the haematotoxicity and protect against cisplatin induced toxicity. |
| Description: | Not Available |
| ISSN: | 2277-7695 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | The Pharma Innovation Journal |
| Journal Type: | Peer reviewed Journal |
| NAAS Rating: | 5.23 |
| Volume No.: | 12(2) |
| Page Number: | 626-632 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://www.thepharmajournal.com/archives/2023/vol12issue2/PartH/12-2-52-228.pdf |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/76077 |
| Appears in Collections: | AS-NIVEDI-Publication |
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