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http://krishi.icar.gov.in/jspui/handle/123456789/76827
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Swain PS | en_US |
dc.contributor.author | Rajendran D | en_US |
dc.contributor.author | Rao SBN | en_US |
dc.contributor.author | Gowda NKS | en_US |
dc.contributor.author | Krishnamoorthy P | en_US |
dc.contributor.author | Mondal S | en_US |
dc.contributor.author | Mor | en_US |
dc.contributor.author | Selvaraj S | en_US |
dc.date.accessioned | 2023-04-12T07:24:06Z | - |
dc.date.available | 2023-04-12T07:24:06Z | - |
dc.date.issued | 2022-07-25 | - |
dc.identifier.citation | Swain, P.S., Rajendran, D., Rao, S.B.N. et al. Nano Zinc Supplementation Affects Immunity, Hormonal Profile, Hepatic Superoxide Dismutase 1 (SOD1) Gene Expression and Vital Organ Histology in Wister Albino Rats. Biol Trace Elem Res 201, 2416–2426 (2023). | en_US |
dc.identifier.issn | 0163-4984 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/76827 | - |
dc.description | Not Available | en_US |
dc.description.abstract | The study was conducted to assess nano zinc (ZnN) as a feed supplement with an aim to compare the supplemental dose of inorganic zinc (ZnI). ZnN was synthesized from 0.45 molar (M) zinc nitrate [Zn(NO3)2.6H2O] and 0.9 M sodium hydroxide (NaOH) and was confirmed to be of ZnN by TEM-EDAX measurements. Wister albino rats (rats; 84, 53.6 ± 0.65 g) were divided into seven groups (4 replicate with 3 rats each) and given feed supplemented with zinc for 60 days with either of the following diets: (1) normal control (NC): basal diet (BD) + no supplemental Zn; (2) ZnI-25: BD + 25 mg/kg Zn from inorganic ZnO; (3) ZnN-25: BD + 25 mg/kg of ZnN; (4) ZnN-12.5: BD + 12.5 mg/kg of ZnN; (5) ZnN-6.25: BD + 6.25 mg/kg of ZnN; (6) ZnN-3.125: BD + 3.125 mg/kg of ZnN; (7) ZnN-50: BD + 50 mg/kg of ZnN. T3 and insulin-like growth factor-1 (IGF-1) hormone levels were similar among groups (P > 0.05), whereas T4 and testosterone were significantly affected, based on supplemented dose. Zn supplementation improved both cell-mediated and humoral immunity. However, both cell-mediated immunity at 24 h and humoral immunity were statistically similar in ZnI-25 and ZnN-6.25 groups. Superoxide dismutase 1 gene expression was found to be similar in all experimental groups. The vascular degeneration were found in liver tissues moderately in NC, mildly in ZnN-6.25 and ZnN-3.125 groups, and no observable changes were noticed in kidney and spleen tissues. However, there was a mild damage in intestinal epithelium of ZnN-25 group rats, hyperplasia of goblet cells, and moderate damage in intestinal villi were observed in ZnN-50 group rats. From the study, it can be concluded that ZnN at half the dose of ZnI showed similar or better responses in terms of immunity, SOD-1 expression, hormonal profiles, and the tissue architecture of vital organs in rats, i.e., 25 mg/kg of Zn from ZnI and 12.5 mg/kg of ZnN impacted similar biological responses like immunity, SOD-1 expression, hormonal profiles, and the tissue architecture of vital organs in rats. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Immunity status | en_US |
dc.subject | Nano Zn | en_US |
dc.subject | Organ architecture | en_US |
dc.subject | Rats | en_US |
dc.subject | Superoxide dismutase-1 (SOD1) gene expression | en_US |
dc.title | Nano zinc supplementation affects immunity, hormonal profile, hepatic superoxide dismutase 1 (SOD1) gene expression and vital organ histology in Wistar albino Rats | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Biological Trace Element Research | en_US |
dc.publication.volumeno | 201 | en_US |
dc.publication.pagenumber | 2416-2426 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | 10.1007/s12011-022-03355-8 | en_US |
dc.publication.authorAffiliation | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics | en_US |
dc.publication.authorAffiliation | ICAR-National Institute of Animal Nutrition and Physiology, Bangalore, | en_US |
dc.publication.authorAffiliation | Dairy Cattle Nutrition Division, ICAR- National Dairy Research Institute, Karnal, Haryana, | en_US |
dc.publication.authorAffiliation | Fisheries and Animal Resources Development Department, Government of Odisha, Baranga, Cuttack, | en_US |
dc.publication.authorAffiliation | ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bangalore, 560064, India | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.journaltype | Peer reviewed Journal | en_US |
dc.publication.naasrating | 9.74 | en_US |
dc.publication.impactfactor | 4.081 | en_US |
Appears in Collections: | AS-NIVEDI-Publication |
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