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http://krishi.icar.gov.in/jspui/handle/123456789/76847
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kiran Kumar B | en_US |
dc.contributor.author | Kumar KM | en_US |
dc.contributor.author | Manjunatha Reddy GB | en_US |
dc.contributor.author | Yogisharadhya R | en_US |
dc.contributor.author | Prashantha CN | en_US |
dc.contributor.author | Awalagaway Dhulappa | en_US |
dc.date.accessioned | 2023-04-13T06:33:04Z | - |
dc.date.available | 2023-04-13T06:33:04Z | - |
dc.date.issued | 2022-04-25 | - |
dc.identifier.citation | Kiran Kumar B, Kumar KM, Manjunatha Reddy GB, Yogisharadhya R, Prashantha CN and Awalagaway Dhulappa. (2022). GC-MS Analysis, Molecular Docking and pharmacokinetic studies of various bioactive compounds from methanolic leaf extracts of Leucas aspera (L) against anti - Capripox viral activity. Chemical Data Collections, 100873. DOI: https://doi.org/10.1016/j.cdc.2022.100873 | en_US |
dc.identifier.issn | 2405-8300 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/76847 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Capripox viruses in the poxviridae family show an emerging worldwide threat to small ruminants. And they cause severe poxviral infection with high mortality and morbidity rates making them potentially useful for economic bioterrorism. This research investigated and evaluated GCMS bioactive compounds from methanolic leaf extract of Leucas aspera by targeting the Capripox viral RNA polymerase and p32 immunogenic proteins using in silico molecular docking approaches with FDA approved drugs. Through GC MS analysis 19 phytochemical compounds were detected in methanolic leaf extracts. Among all five phytochemicals Imidazole 4 2amino1methylethyl n Hexylmethane sulfonamide N E 4 Bromophenyl methylidene 4 methyl benzohydrazide 2 6 Dimethyl benzaldehyde carbamoyl hydrazone methyl N hydroxybenzene carboximidate was accepted as a potent drug like compound through pharmacokinetic. The discovery of antiviral drugs is of immense significance in reducing the incidence of novel poxvirus infections both economically and geographically. Thus the present study may lead to the development of novel Anti Capripox viral drugs using Leucas aspera in the development of herbal medicines for various ailments. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Not Available | en_US |
dc.title | GC-MS Analysis Molecular Docking and pharmacokinetic studies of various bioactive compounds from methanolic leaf extracts of Leucas aspera (L) against antiCapripox viral activity | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Chemical Data Collections | en_US |
dc.publication.volumeno | 100873 | en_US |
dc.publication.pagenumber | 100873 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | https://doi.org/10.1016/j.cdc.2022.100873 | en_US |
dc.publication.authorAffiliation | Department of Biotechnology, REVA University, Bengaluru, India | en_US |
dc.publication.authorAffiliation | National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru, India | en_US |
dc.publication.authorAffiliation | Department of Bioinformatics, Pondicherry central University, Pondicherry, India | en_US |
dc.publication.authorAffiliation | Dept of Microbiology, Maharani's Science College for women, Bengaluru. India | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.journaltype | peer reviewed journal | en_US |
dc.publication.naasrating | Not Available | en_US |
dc.publication.impactfactor | Not Available | en_US |
Appears in Collections: | AS-NIVEDI-Publication |
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