KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/77260
Title: | Exploring the possible use of saponin adjuvants in COVID-19 vaccine |
Other Titles: | Not Available |
Authors: | Not Available Rinku Sharma , Arivukarasu Palanisamy , Kuldeep Dhama , Gorakh Mal , Birbal Singh & Karam Pal Singh |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::Indian Veterinary Research Institute |
Published/ Complete Date: | 2020-12-01 |
Project Code: | IVRI/PALAM/17-19/013 |
Keywords: | Saponin adjuvant; immunostimulation; viral vaccines; COVID-19 vaccine |
Publisher: | Taylor and Francis |
Citation: | Not Available |
Series/Report no.: | Not Available; |
Abstract/Description: | There is an urgent need for a safe, efficacious, and cost-effective vaccine for the coronavirus disease 2019 (COVID-19) pandemic caused by novel coronavirus strain, severe acute respiratory syndrome-2 (SARS-CoV -2). The protective immunity of certain types of vaccines can be enhanced by the addition of adjuvants. Many diverse classes of compounds have been identified as adjuvants, including mineral salts, microbial products, emulsions, saponins, cytokines, polymers, microparticles, and liposomes. Several saponins have been shown to stimulate both the Th1-type immune response and the production of cytotoxic T lymphocytes against endogenous antigens, making them very useful for subunit vaccines, especially those for intracellular pathogens. In this review, we discuss the structural characteristics, mechanisms of action, structure–activity relationship of saponins, biological activities, and use of saponins in various viral vaccines and their applicability to a SARS-CoV-2 vaccine. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Review Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Human Vaccines and Immunotherapeutics |
Journal Type: | Included NAAS journal list |
Impact Factor: | 4.526 |
Volume No.: | Not Available |
Page Number: | Not Available |
Name of the Division/Regional Station: | ICAR-IVRI Regional Station, Palampur |
Source, DOI or any other URL: | Not Available https://doi.org/10.1080/21645515.2020.1833579 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77260 |
Appears in Collections: | AS-IVRI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.