KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/77270
Title: | Orf: an update on current research and future perspectives. |
Authors: | Hosamani M, Scagliarini A, Bhanuprakash V, McInnes CJ, Singh RK. |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR-Indian Veterinary Research Institute |
Published/ Complete Date: | 2009-09-01 |
Keywords: | Orf, Update, Research prospective |
Publisher: | Taylor and Francis |
Abstract/Description: | Orf is one of the most widespread viral diseases worldwide, affecting mostly small ruminants and, sometimes, other species, including wild animals. Of late, there have been an increasing number of reports of new species being affected by the disease, implying a dynamic host-pathogen interaction. The causative agent, orf virus, has been extensively investigated over recent years, owing to its zoonotic importance and ability to cross-infect other species sporadically. The evasive mechanisms that the virus has developed to adapt and grow in the presence of an active immune response helps to explain the ability of the virus to repeatedly reinfect the same host. The apparent diversity in the antigenic/immune targets of different orf virus strains involved in such repeat infections may also be contributing factors. Exposure of animals to stress or immunosupression as a result of therapy or primary viral infection can accentuate the severity of disease. Genes homologous to host cytokines or their antagonists, and which contribute to viral virulence, have been found in the viral genome. A combination of electron microscopy, histology and PCR is the most accurate laboratory approach for confirmation of the disease, although clinical signs are often typical. However, some infections may be confounded by similar clinical manifestations caused by other infections. This review presents, in brief, a recent understanding of the virus at the host-pathogen level, molecular biology of the virus, disease epidemiology, clinical manifestations in man and animals, diagnostic procedures, and the economic and environmental impact of the disease. |
Type(s) of content: | Review Paper |
Language: | English |
Name of Journal: | Expert Review of Antiinfective Therapy |
Journal Type: | Included in NAAS Journal List |
NAAS Rating: | 11.85 |
Impact Factor: | 5.41 |
Volume No.: | 7(7) |
Page Number: | 879-893 |
Name of the Division/Regional Station: | ICAR-IVRI, HA Farm, Hebbal, Bengaluru 560024, Karnataka |
Source, DOI or any other URL: | 10.1586/eri.09.64 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77270 |
Appears in Collections: | AS-IVRI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.