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http://krishi.icar.gov.in/jspui/handle/123456789/77493
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Umesha K, Sarojini BK, Darshan Raj CG, Bhanuprakash V, Yogisharadhya R, Raghavendra R, Mahmud T, Khan H | en_US |
dc.date.accessioned | 2023-05-16T09:44:38Z | - |
dc.date.available | 2023-05-16T09:44:38Z | - |
dc.date.issued | 2013-05-23 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/77493 | - |
dc.description.abstract | In the present study, we report the synthesis,characterization of new series of thiazolo[3,2-a]pyrimi-dine-6-carboxylate derivatives 3a–f and 4a–f. The newlysynthesized compounds were screened for in vitro antimi-crobial and antiviral activities. The probable mode ofaction of these active compounds was determined throughin silico docking study by docking the receptor methionyl-tRNA synthetase and human inosine-50-monophosphatedehydrogenase (IMPDH) for antibacterial and antiviralactivities, respectively. Among the compounds, 4c exhib-ited excellent in vitro antimicrobial activity against alltested strains with binding and docking energies -35.6 and-12.4 kcal/mol, respectively. The antiviral studies werecarried out for the selected compounds in which 4aexhibited 73.69 and 54.42 % of inhibition of buffalopoxand camelpox viruses, respectively. Furthermore, com-pound 4a showed minimum docking and binding energyalong with the maximum hydrogen/hydrophobic interac-tion with IMPDH. The study contributes towards identifi-cation and screening of potential antimicrobial andantiviral agent’s against the pathogens | en_US |
dc.language.iso | English | en_US |
dc.publisher | Springer | en_US |
dc.subject | Thiazolo[3,2-a]pyrimidine-6-carboxylate, In vitro antimicrobial activity, In vitro antiviral activity,In silico docking studies | en_US |
dc.title | In vitro and in silico biological studies of novel thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives | en_US |
dc.type | Research Paper | en_US |
dc.publication.journalname | MEDICINALCHEMISTRY RESEARCH | en_US |
dc.publication.volumeno | 23[1] | en_US |
dc.publication.pagenumber | 1-13 | en_US |
dc.publication.divisionUnit | ICAR-IVRI, HA Farm, Hebbal, Bengaluru 560024, Karnataka | en_US |
dc.publication.sourceUrl | 10.1007/s00044-013-0606-4 | en_US |
dc.publication.authorAffiliation | ICAR-Indian Veterinary Research Institute | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.journaltype | Included in NAAS Journal List | en_US |
dc.publication.naasrating | 8.35 | en_US |
dc.publication.impactfactor | 2.351 | en_US |
Appears in Collections: | AS-IVRI-Publication |
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