KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/77566
Title: | No change in mRNA expression of immune-related genes in peripheral blood mononuclear cells challenged with Theileria annulata in Murrah buffalo (Bubalus bubalis) |
Other Titles: | Not Available |
Authors: | Panigrahi M, Kumar A, Bhushan B, Ghosh S, Saravanan BC, Sulabh S, Parida S, Gaur GK. |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::Indian Veterinary Research Institute |
Published/ Complete Date: | 2016-03-09 |
Project Code: | Not Available |
Keywords: | Buffalo; Hyalomma tick; Immune-related genes; Theileria annulata. |
Publisher: | Elsevier |
Citation: | Panigrahi M, Kumar A, Bhushan B, Ghosh S, Saravanan BC, Sulabh S, Parida S, Gaur GK. No change in mRNA expression of immune-related genes in peripheral blood mononuclear cells challenged with Theileria annulata in Murrah buffalo (Bubalus bubalis). Ticks Tick Borne Dis. 2016 Jul;7(5):754-758. doi: 10.1016/j.ttbdis.2016.03.006. Epub 2016 Mar 14. PMID: 26997138. |
Series/Report no.: | Not Available; |
Abstract/Description: | Water buffaloes (Bubalus bubalis) act as carrier to Theileria annulata and show less clinical sign of tropical theileriosis as compared to indigenous and exotic cattle. Differential expression of immune-related genes such as major histocompatibility complex, class II, DQ alpha 1 (MHC-DQα), signal-regulatory protein alpha (SIRPA), prion protein (PRNP), Toll-like receptor 10 (TLR10), c-musculoaponeurotic fibrosarcoma oncogene homolog (cMAF) and V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) genes influence host resistance to this disease in exotic, crossbred and indigenous cattle. In the present study we examined the differential mRNA expression of the abovesaid immune-related genes in response to T. annulata infection in buffaloes. Peripheral blood mononuclear cells (PBMCs) harvested from blood samples of buffaloes were challenged with ground-up tick supernatant carrying T. annulata sporozoites in vitro. After 48h of in vitro challenge qPCR was employed to measure the relative mRNA expression of MHC-DQα, SIRPA, PRNP, TLR10, cMAF and MAFB genes in infected and control PBMCs. In the current study, the selected genes showed no change in mRNA expression after T.annulata infection which indicates that they have little role in providing host resistance to theileriosis in buffaloes. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Article |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Ticks and Tick-borne diseases |
Journal Type: | Included NAAS journal list |
NAAS Rating: | 9.82 |
Impact Factor: | 3.817 |
Volume No.: | Not Available |
Page Number: | Not Available |
Name of the Division/Regional Station: | Division of Pharmacology and Toxicology, ICAR-IVRI |
Source, DOI or any other URL: | https://doi.org/10.1016/j.ttbdis.2016.03.006 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77566 |
Appears in Collections: | AS-IVRI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.