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http://krishi.icar.gov.in/jspui/handle/123456789/77767
Title: | Atorvastatin along with imipenem attenuates acute lung injury in sepsis through decrease in inflammatory mediators and bacterial load |
Other Titles: | Not Available |
Authors: | Choudhury S, Kandasamy K, Maruti BS, Addison MP, Kasa JK, Darzi SA, Singh TU, Parida S, Dash JR, Singh V, Mishra SK. |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::Indian Veterinary Research Institute |
Published/ Complete Date: | 2015-10-15 |
Project Code: | Not Available |
Keywords: | Atorvastatin; Imipenem; Lung injury; Sepsis. |
Publisher: | Elsevier |
Citation: | Choudhury S, Kandasamy K, Maruti BS, Addison MP, Kasa JK, Darzi SA, Singh TU, Parida S, Dash JR, Singh V, Mishra SK. Atorvastatin along with imipenem attenuates acute lung injury in sepsis through decrease in inflammatory mediators and bacterial load. Eur J Pharmacol. 2015 Oct 15;765:447-56. doi: 10.1016/j.ejphar.2015.09.009. Epub 2015 Sep 14. PMID: 26375251. |
Series/Report no.: | Not Available; |
Abstract/Description: | Lung is one of the vital organs which is affected during the sequential development of multi-organ dysfunction in sepsis. The purpose of the present study was to examine whether combined treatment with atorvastatin and imipenem could attenuate sepsis-induced lung injury in mice. Sepsis was induced by caecal ligation and puncture. Lung injury was assessed by the presence of lung edema, increased vascular permeability, increased inflammatory cell infiltration and cytokine levels in broncho-alveolar lavage fluid (BALF). Treatment with atorvastatin along with imipenem reduced the lung bacterial load and pro-inflammatory cytokines (IL-1β and TNFα) level in BALF. The markers of pulmonary edema such as microvascular leakage and wet-dry weight ratio were also attenuated. This was further confirmed by the reduced activity of MPO and ICAM-1 mRNA expression, indicating the lesser infiltration and adhesion of inflammatory cells to the lungs. Again, expression of mRNA and protein level of iNOS in lungs was also reduced in the combined treatment group. Based on the above findings it can be concluded that, combined treatment with atorvastatin and imipenem dampened the inflammatory response and reduced the bacterial load, thus seems to have promising therapeutic potential in sepsis-induced lung injury in mice. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Article |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | European Journal of Pharmacology |
Journal Type: | Included NAAS journal list |
NAAS Rating: | 11.20 |
Impact Factor: | 4.432 |
Volume No.: | Not Available |
Page Number: | Not Available |
Name of the Division/Regional Station: | Division of Pharmacology and Toxicology, ICAR-IVRI |
Source, DOI or any other URL: | https://doi.org/10.1016/j.ejphar.2015.09.009 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77767 |
Appears in Collections: | AS-IVRI-Publication |
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