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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/81913
Title: | Porcine Circovirus type 2 infected myocardial tissue transcriptome signature |
Other Titles: | Not Available |
Authors: | Rajib Deb, Joyshikh Sonowal, Gyanendra Singh Sengar, Seema Rani Pegu, Manas Ranjan Praharaj, Waseem Akram Malla, Indra Singh, Ajay Kumar Yadav, Swaraj Rajkhowa, Pranab Jyoti Das, Jaya Bharati, Souvik Paul, Vivek Kumar Gupta |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Research Centre on Pig |
Published/ Complete Date: | 2022-08-20 |
Project Code: | Not Available |
Keywords: | porcine; pig; gene |
Publisher: | Not Available |
Citation: | Deb, R., Sonowal, J., Sengar, G. S., Pegu, S. R., Praharaj, M. R., Malla, W. A., ... & Gupta, V. K. (2022). Porcine Circovirus type 2 infected myocardial tissue transcriptome signature. Gene, 836, 146670. |
Series/Report no.: | Not Available; |
Abstract/Description: | The goal of this study was to compare the global gene expression profile in cardiac tissues of pig infected with porcine circovirus 2 (PCV2) to that of healthy cells. Since PCV2 infection causes severe cardiovascular lesions, the myocardial tissue model was chosen for this study. In High-throughput transcriptome analysis, DESeq2 and CLC genomics workbench analyses revealed a total of 196 significantly differentially expressed genes (DEGs) (p-value < 0.05). Furthermore, 194 transcripts were upregulated, while only two were downregulated (HSPA6 and DNAJA1), with fold changes ranging from 16.293 to −10.002. Among the KEGG canonical pathways targeted by the DEGs in the functional analysis, adrenergic signalling in cardiomyocytes, Cardiac Muscle Contraction, Hypertrophic Cardiomyopathy (HCM), and Dilated Cardiomyopathy (DCM) tends to be enriched. The differentially expressed highly connected (DEHC) biomarker genes in pathogenicity of PCV2 infection, such as LDB3, MYOZ2, CASQ2, TNNT2, MLC2V, MYBPC3, ACTC1, TCAP, TNNI3, TRDN, CSRP3, MYL3, RYR2, LMOD2, MYH7, etc., were identified using protein–protein interaction (PPI) network analysis. The study might provide detailed information on the dysregulated genes and biological pathways in infected myocardial tissues that may be essential for PCV2-related heart pathology. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Article |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Gene |
Journal Type: | NAAS Listed |
NAAS Rating: | 9.50 |
Impact Factor: | 3.5 |
Volume No.: | 836 |
Page Number: | 146670 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | https://doi.org/10.1016/j.gene.2022.146670 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/81913 |
Appears in Collections: | AS-NRCP-Publication |
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