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Genome-wide identification of transcriptional regulators and functional characterization in Candida albicans

Shodhganga@INFLIBNET

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Title Genome-wide identification of transcriptional regulators and functional characterization in Candida albicans
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Contributor Natarajan, K
 
Subject Life Science
Candida albicans
Genome-wide
transcriptional regulators
 
Description ABSTRACT
newlineThe post-genome sequencmg era heralds new avenues to explore the biology of
newlineorganisms hitherto considered genetically intractable. While genomics is not typically
newlinethought of as hypothesis-driven science, comparative genomics presents an opportunity
newlineto generate many new hypotheses. Genome annotation predicts where the functional
newlineelements of the genome are located and provides a starting point for directed
newlineexperiments. Comparative genomics is a filter to identify regions of the genome that
newlinehave undergone particular evolutionary changes and helps to establish the genetic bases
newlineof phenotypic differences.
newlineThe kingdom Fungi is comprised of organisms that thrive in diverse habitats
newlinesuch as decaying organic matter or as plant and animal pathogens. Comparative
newlinegenomics has helped the study of fungal evolution and provided a framework for
newlineidentifying patterns of change in gene content and structure among species. A
newlinecomparison of different fungi across lineages would illustrate how adaptive changes to
newlinehabitats or lifestyles are manifested in the genome. Comparative genomics can also
newlineidentify lineage-specific gene family expansions indicative of particular mechanisms
newlinefor species adaptation. With the advancement of genomic technologies sequencing of
newlinearound 80 fungal species are in the public domain and -50 more sequences covering all
newlinethe lineages are in various stages of completion. Several related fungal genomes have
newlinebeen sequenced so as to enable comparative analysis across a range of evolutionary
newlinedistances. These clusters also include related organisms that differ in terms of specific
newlinephysiological traits (i.e., pathogenicity), thus allowing these traits to be explored
newlinethrough comparison. The growing complement of fungal genome sequences enables
newlineother strategies for investigating fungal infection. Comparing genomes from
newlinenonpathogenic species to related pathogenic organisms can identify genetic differences
newlinethat contribute to infection and disease, while the comparison between strains with
newlinedifferent host specifici
Bibliography p.136-151
 
Date 2013-12-30T08:37:12Z
2013-12-30T08:37:12Z
2013-12-30
n.d.
2008
n.d.
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/14305
 
Language English
 
Relation -
 
Rights university
 
Format 151p.
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None
 
Coverage Life Sciences
 
Publisher Delhi
Jawaharlal Nehru University
School of Life Sciences
 
Source INFLIBNET