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Functional genomics of bZIP transcriptional regulators in Candida albicans

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Title Functional genomics of bZIP transcriptional regulators in Candida albicans
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Contributor Natarajan, K
 
Subject Life Science
bZIP transcriptional regulators
Functional genomics
Candida albicans
 
Description Candida albicans is an opportunistic fungal pathogen found in the normal
newlinegastrointestinal flora of most healthy humans. However, in immuno-compromised
newlinepatients, blood stream infections often cause death, despite the use of anti-fungal
newlinetherapies. The growth and survival of all microbes is dependent upon their ability to
newlinedetect and respond to envirolnnental changes. C. albicans virulence is a polygenic
newlinetrait, one of which is its ability to undergo reversible morphological transitions
newlinebetween yeast, pseudohyphal and hyphal growth forms. Numerous conditions
newlinepromote yeast-hypha morphogenesis in vitro, including growth of C. albicans at
newlinetemperatures gt35°C, serum, neutral pH and nutrient starvation. These presumably
newlinereflect signals that control morphogenesis in vivo. Genetic analyses have revealed
newlineother virulence factors including adhesion to host tissues, biofilm formation, and
newlineability to use lipids as energy source via the glyoxylate pathway among others. A
newlinegreat majority of transcriptional regulators functions by binding to promoter DNA and
newlineup- or down-regulate transcription from target promoters. It has also been recognized
newlinein studies from other systems that host-pathogen interaction causes genome-wide
newlineexpression profile. Therefore it becomes important to identify and characterize the
newlinefull complement of the transcriptional regulators that mediate these responses.
newlineC. albicans genome size is -16 Mbp distributed in eight pairs of homologous
newlinechromosomes which are numbered from 1 (largest) to 7 (smallest) and R (ribosomal
newlineDNA). The assembly of complete C. albicans diploid genome sequence identified
newline-14220 ORFs that are~ 100 amino acids and the full genome annotation has become
newlinerecently available. Genome sequence analysis has uncovered many C. albicans ORFs
newlinethat have similarity to S. cerevisiae and other fungi, but that are completely absent
newlinefrom mammalian genomes. Theoretically, the products ofthese genes would! represent
newlineattractive antifungal drug targets. Genome sequence analysis also revealed many
newlineORFs that a
Bibliography p.174-188
 
Date 2013-12-30T08:48:12Z
2013-12-30T08:48:12Z
2013-12-30
n.d.
2008
n.d.
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/14306
 
Language English
 
Relation -
 
Rights university
 
Format 188p.
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None
 
Coverage Life Sciences
 
Publisher Delhi
Jawaharlal Nehru University
School of Life Sciences
 
Source INFLIBNET